Harmane
Harmane (CAS: 486-84-0, C12H10N2, MW: 182.22) is a bioactive small molecule and a heterocyclic building block. It is known for its use in biological research, including studies on DNA interactions and as a matrix in analytical techniques like mass spectrometry for glycan analysis. Its applications extend to cell biology and neuroscience research.
- IUPAC
- 1-Methyl-9H-pyrido[3,4-b]indole,2-Methyl-β-carboline,Aribine
- Synonyms
- 2-Methyl-β-carbolineAribine1-Methyl-9H-pyrido[3,4-b]indole
Analytical Chemistry
Harmane serves as a matrix in mass spectrometry for the analysis of cyclodextrins and sulfated oligosaccharides. It has also been used in the trace level determination of harmane itself using planar chromatography coupled with mass spectrometry.
Biological Research
This compound has been employed to investigate the interactions between norharman and harman with DNA. Its use in cell biology and neuroscience research highlights its role in understanding cellular signaling pathways.
Chemical Synthesis
As a carbazole derivative and heterocyclic building block, Harmane is valuable in organic synthesis for constructing more complex molecular architectures.
| Molecular weight | 182.22 |
|---|---|
| Empirical formula | C12H10N2 |
| Assay | 98% |
| Solubility | methanol: soluble50mg/ml |
| Application | • Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry1. • It was used to study interactions of norharman and harman with DNA2.• It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix. |
| Melting point | 235-238 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Drug Control | stup |
|---|---|
| Gene Information | human ... CYP2D6(1565)rat ... Gabra2(29706) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Harmane used for?
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Harmane is used in analytical chemistry as a matrix for mass spectrometry, in biological research to study DNA interactions and cellular signaling, and in chemical synthesis as a building block.
What are the CAS number and formula for Harmane?
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The CAS number for Harmane is 486-84-0 and its molecular formula is C12H10N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Harmane with an assay of 98%. This product is intended for research and laboratory use and is not supplied as USP, BP, or EP grade.
How should Harmane be handled safely?
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Safe handling requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It is classified under WGK 3 in Germany.
Is Harmane a controlled substance?
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Harmane is classified as a 'stup' under drug control regulations.
How is Harmane packaged and shipped?
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Harmane is carefully packaged to ensure safe transit and is exported globally by Tech Serve Solutions. Specific packaging details are available upon request.
How can I request a sample or quote for Harmane?
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To request a sample or obtain a quote for Harmane, please contact our sales team through the website or by phone.
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