Harmaline
Harmaline (CAS: 304-21-2), a bioactive alkaloid with the chemical formula C13H14N2O and a molecular weight of 214.26 g/mol, is a key chemical intermediate. Its structure serves as a natural product scaffold for the development of novel therapeutic agents. Harmaline is utilized in chemical synthesis, particularly in the preparation of acylated derivatives and phenacyl compounds with potential central nervous system activity, as well as in research exploring anti-tumour agents.
- IUPAC
- 1-Methyl-7-methoxy-3,4-dihydro-β-carboline,4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indole,Dihydroharmine,Harmalol methyl ether,Harmidine,NSC 407285
- Synonyms
- 1-Methyl-7-methoxy-3,4-dihydro-β-carboline4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indoleDihydroharmineHarmalol methyl etherHarmidineNSC 407285
Preparation of Acylated Harmalines
Harmaline serves as a reactant for the preparation of acylated harmalines through Friedel-Crafts reactions. This process is fundamental in modifying the harmaline structure for further chemical investigations.
Synthesis of CNS-Active Compounds
It is used in the synthesis of phenacyl derivatives of 1-methyl-7-methoxy-β-carbolines. These compounds are investigated for their potential as central nervous system affectors.
Development of Anti-Tumour Agents
Harmaline is employed in the preparation of palladium harmaline DMSO chloro complex, which is researched for its potential anti-tumour properties.
Natural Product Scaffold
The compound acts as a natural product scaffold in the preparation of various molecules, including research into trypanothione reductase inhibitors.
| Molecular weight | 214.26 |
|---|---|
| Empirical formula | C13H14N2O |
| Application | Reactant for preparation of:• Acylated harmalines via Friedel-Crafts reaction1• Phenacyl derivatives of 1-methyl-7-methoxy-β-carbolines as central nervous system affectors2• Palladium harmaline DMSO chloro complex as anti-tumor agent3Natural product scaffold in preparation of:• Trypanothione reductase inhibitors† |
| Melting point | 232-234 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Drug Control | stup |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Harmaline used for?
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Harmaline is used as a reactant for the preparation of acylated harmalines, phenacyl derivatives with potential CNS activity, palladium harmaline DMSO chloro complex as an anti-tumour agent, and as a natural product scaffold for trypanothione reductase inhibitors.
What is the CAS number and formula for Harmaline?
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The CAS number for Harmaline is 304-21-2, and its chemical formula is C13H14N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Harmaline as a research-grade chemical. TSS does not represent this product as USP, BP, or EP grade. Purity details are available upon request.
How is Harmaline packed and shipped?
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Harmaline is carefully packed and exported by Tech Serve Solutions in compliance with all relevant shipping regulations for chemical compounds.
How can I request a quote or sample for Harmaline?
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To request a quote or sample for Harmaline, please contact our sales team through the website or by phone.
What are the safety precautions for handling Harmaline?
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Harmaline requires the use of safety equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Refer to the Safety Data Sheet for comprehensive handling instructions.
Is Harmaline a controlled substance?
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Harmaline is listed as a controlled substance (stup).
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