GW4869

CAS 6823-69-4C30H28N6O2 · 2HClBiochemicals & Reagents

GW4869 (CAS 6823-69-4), a dihydrochloride salt with the molecular formula C30H28N6O2 · 2HCl and a molecular weight of 577.50, is a potent inhibitor of neutral sphingomyelinase. This compound serves as a valuable biochemical reagent for research applications, particularly in cell biology and neuroscience. Its ability to modulate cellular signaling pathways makes it an important tool for investigating lysosomal function and related biological processes.

IUPAC: N,N′-Bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-3,3′-p-phenylene-bis-acrylamide dihydrochloride

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GW4869 (C30H28N6O2 · 2HCl) — chemical structure, CAS 6823-69-4; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesGlaxoSmithKlineR to Z

01 /Applications

Sphingomyelinase Inhibition

GW4869 is widely used as a specific inhibitor of neutral sphingomyelinase (nSMase) activity. This property is crucial for researchers studying the role of sphingolipids in various cellular processes.

Cell Biology Research

This compound aids in the investigation of cell membrane dynamics, apoptosis, and autophagy. Its application helps elucidate the complex signaling cascades regulated by sphingomyelinase.

Neuroscience Studies

GW4869 is employed in neuroscience research to explore the involvement of sphingomyelinase in neuronal function and disease. It assists in understanding neurodegenerative processes and therapeutic targets.

Drug Discovery and Development

As an approved therapeutic candidate and bioactive small molecule, GW4869 is a subject of interest in drug discovery for conditions influenced by sphingomyelinase activity.

02 /Properties

Molecular weight	577.50
Empirical formula	C30H28N6O2 · 2HCl
Assay	≥90% (NMR)
Form	powder
Colour	light yellow to yellow
Solubility	DMSO: soluble0.2 mg/mL
Storage temperature	2-8°C
Melting point	>300 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

6823-69-4

05 /Additional specifications

Storage Condition	desiccatedprotect from light

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is GW4869 used for?

GW4869 is primarily used as a research tool for inhibiting neutral sphingomyelinase (nSMase) activity, aiding studies in cell biology, neuroscience, and sphingolipid metabolism.

What are the CAS number and formula for GW4869?

The CAS number for GW4869 is 6823-69-4, and its formula is C30H28N6O2 · 2HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies GW4869 with a purity of ≥90% (NMR). We do not represent this product as USP, BP, or EP grade; it is intended for research and laboratory use.

How should GW4869 be handled and stored?

GW4869 is a light yellow to yellow powder. Handle with appropriate personal protective equipment including eyeshields and gloves. It should be stored desiccated and protected from light at 2-8°C. Users should consult the safety data sheet for detailed handling information.

How is GW4869 shipped and exported?

Tech Serve Solutions professionally packs, handles, and exports GW4869 according to international shipping regulations for chemical compounds. Please contact us for specific export inquiries.

How can I request a sample or quote for GW4869?

To request a sample or obtain a quote for GW4869, please contact our sales team through the website or by calling us directly. Provide the product name and CAS number.