Fmoc-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH (CAS: 143824-78-6), with the molecular formula C31H30N2O6 and a molecular weight of 526.58 g/mol, is a protected derivative of the amino acid tryptophan. It is primarily utilised in solid-phase peptide synthesis (SPPS) to incorporate tryptophan residues into peptide chains while preventing side-chain reactions. This compound is essential for researchers in chemical biology and peptide chemistry, facilitating the construction of complex peptides.
- IUPAC
- Nα-Fmoc-N(in)-Boc-L-tryptophan,N(in)-Boc-Nα-Fmoc-L-tryptophan
- Synonyms
- Nα-Fmoc-N(in)-Boc-L-tryptophanN(in)-Boc-Nα-Fmoc-L-tryptophan
Peptide Synthesis
Fmoc-Trp(Boc)-OH is a key building block in the Fmoc/tBu solid-phase peptide synthesis strategy. The Nα-Fmoc group allows for base-labile deprotection, while the N(in)-Boc group protects the indole nitrogen from unwanted reactions during peptide chain elongation.
Chemical Biology Research
This protected amino acid derivative is employed in the synthesis of peptides and peptidomimetics for various applications in chemical biology, including the development of therapeutic agents and biological probes.
Organic Synthesis
Beyond peptide synthesis, Fmoc-Trp(Boc)-OH can serve as a chiral building block in complex organic synthesis, enabling the stereoselective construction of molecules containing tryptophan-like structures.
| Molecular weight | 526.58 |
|---|---|
| Empirical formula | C31H30N2O6 |
| Assay | ≥97.0% (HPLC) |
| Optical activity | [α]20/D −21±2°, c = 1% in DMF |
| Storage temperature | 2-8°C |
Hazard statements
- H317May cause an allergic skin reaction
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi,N |
| Risk statements (R) | 43-51/53 |
| Safety statements (S) | 22-24-37-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-Trp(Boc)-OH used for?
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Fmoc-Trp(Boc)-OH is primarily used as a protected amino acid derivative in solid-phase peptide synthesis (SPPS) to incorporate tryptophan residues into peptide chains. It is also utilised in chemical biology and organic synthesis.
What is the CAS number and formula for Fmoc-Trp(Boc)-OH?
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The CAS number for Fmoc-Trp(Boc)-OH is 143824-78-6 and its empirical formula is C31H30N2O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-Trp(Boc)-OH with an assay of ≥97.0% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
How should Fmoc-Trp(Boc)-OH be handled and stored?
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Fmoc-Trp(Boc)-OH is classified as a Warning and may cause an allergic skin reaction (H317) and is toxic to aquatic life with long-lasting effects (H411). Handle with eyeshields and gloves. Use a type N95 (US) or type P1 (EN143) respirator filter. Store at 2-8°C.
How is Fmoc-Trp(Boc)-OH packed and shipped?
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Fmoc-Trp(Boc)-OH is shipped as UN 3077, Class 9, Packing Group III. Specific packing details are available upon request. TSS exports globally.
How can I request a quote or sample for Fmoc-Trp(Boc)-OH?
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Please contact our sales team or use the online request form to obtain a quote or request a sample of Fmoc-Trp(Boc)-OH.
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