Ethyl diazoacetate
Ethyl diazoacetate (CAS: 623-73-4) is an organic compound with the linear formula N=N=CHCOOC2H5 and a molecular weight of 114.10 g/mol. This diazo compound, typically supplied with ≥13 wt.% dichloromethane, serves as a valuable reagent in organic synthesis. It is particularly noted for its role in ruthenium-catalyzed asymmetric cyclopropanation of alkenes, offering a pathway to complex cyclic structures in chemical research and development.
- IUPAC
- DAAE
Asymmetric Cyclopropanation
Ethyl diazoacetate is a key reagent in ruthenium-catalyzed asymmetric cyclopropanation reactions. This application allows for the stereoselective synthesis of cyclopropane rings from alkenes, a foundational step in constructing complex molecular architectures.
Organic Synthesis Building Block
As a versatile building block, ethyl diazoacetate participates in various organic transformations. Its diazo functionality enables its use in reactions such as cyclopropanation and carbene insertions, facilitating the creation of diverse organic molecules.
Reagent in Chemical Research
The compound is frequently employed in academic and industrial research laboratories. Its reactivity profile makes it a useful tool for exploring new synthetic methodologies and for the preparation of novel organic compounds.
| Molecular weight | 114.10 |
|---|---|
| Linear formula | N=N=CHCOOC2H5 |
| Boiling point | 140-141 °C/720 mmHg(lit.) |
| Density | 1.085 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.46(lit.) |
| Storage temperature | 2-8°C |
| Contains / stabiliser | ≥13 wt. % dichloromethane |
| Melting point | −22 °C(lit.) |
| Application | Reagent for ruthenium-catalyzed asymmetric cyclopropanation of alkenes.1 |
Hazard statements
- H226Flammable liquid and vapour
- H242Heating may cause a fire
- H302Harmful if swallowed
- H351Suspected of causing cancer
Precautionary statements
- P281Use personal protective equipment as required
| Flash point | 47 °C / 116.6 °F |
|---|---|
| Transport (UN / ADR) | UN 1993 3/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 5-10-22-40 |
| Safety statements (S) | 36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl diazoacetate primarily used for?
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Ethyl diazoacetate is primarily used as a reagent in ruthenium-catalyzed asymmetric cyclopropanation of alkenes and as a general building block in organic synthesis.
What is the CAS number and formula for Ethyl diazoacetate?
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The CAS number for Ethyl diazoacetate is 623-73-4, and its linear formula is N=N=CHCOOC2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl diazoacetate containing ≥13 wt.% dichloromethane. We do not represent this product as USP, BP, or EP grade.
How should Ethyl diazoacetate be handled and stored?
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Ethyl diazoacetate is flammable (H226) and may form explosive mixtures with air upon heating (H242). It is also harmful if swallowed (H302) and suspected of causing cancer (H351). Store in a cool, well-ventilated place at 2-8°C, away from heat and ignition sources. Handle with appropriate personal protective equipment.
Is Ethyl diazoacetate a controlled substance?
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The provided data does not indicate that Ethyl diazoacetate is a controlled substance. However, users should consult local regulations.
How can I request a quote or sample for Ethyl diazoacetate?
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To request a quote or sample for Ethyl diazoacetate, please contact our sales team through the website or by phone.
How is Ethyl diazoacetate shipped?
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Ethyl diazoacetate is shipped according to relevant dangerous goods regulations (UN 1993 3/PG 3).
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