Ethyl (4-trifluoromethylbenzoyl)acetate
Ethyl (4-trifluoromethylbenzoyl)acetate (CAS: 106263-53-0) is a key organic building block with the linear formula CF<sub>3</sub>C<sub>6</sub>H<sub>4</sub>COCH<sub>2</sub>CO<sub>2</sub>C<sub>2</sub>H<sub>5</sub> and a molecular weight of 260.21 g/mol. This ester, featuring a trifluoromethylbenzoyl group, is utilised as a reactant in various sophisticated chemical syntheses, including cycloisomerisation and stereoselective reductions. Its chemical structure makes it valuable in the development of complex molecules.
- IUPAC
- 3-Oxo-3-(4-trifluoromethylphenyl)propanoic acid ethyl ester,Ethyl 2-4-(Trifluoromethyl)benzoylacetate,Ethyl 3-(4-trifluoromethylphenyl)-3-oxopropionate,Ethyl 3-oxo-3-4-(trifluoromethyl)phenylpropanoate
- Synonyms
- 3-Oxo-3-(4-trifluoromethylphenyl)propanoic acid ethyl esterEthyl 2-4-(Trifluoromethyl)benzoylacetateEthyl 3-(4-trifluoromethylphenyl)-3-oxopropionateEthyl 3-oxo-3-4-(trifluoromethyl)phenylpropanoate
Catalyst for Cycloisomerisation
Ethyl (4-trifluoromethylbenzoyl)acetate serves as a reactant in Indium-catalysed cycloisomerisation reactions. These reactions are important for constructing cyclic organic frameworks.
Stereoselective Reductions
This compound is a substrate in chiral Lewis base-catalyzed stereoselective reductions using trichlorosilane and water. This application is crucial for producing enantiomerically enriched products.
Michael Reactions
It participates in Guanidine-catalysed enantioselective Michael reactions. This facilitates the formation of carbon-carbon bonds with high stereocontrol.
Transesterification and Coupling Reactions
Ethyl (4-trifluoromethylbenzoyl)acetate can be employed in transesterification processes and intermolecular coupling reactions, expanding its utility in synthetic organic chemistry.
| Molecular weight | 260.21 |
|---|---|
| Linear formula | CF3C6H4COCH2CO2C2H5 |
| Boiling point | 248-249 °C(lit.) |
| Density | 1.270 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4880(lit.) |
| Application | Reactant for:• In-catalyzed cycloisomerization1• Chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water2• Guanidine-catalyzed enantioselective Michael reactions3• Transesterification reactions4• Intermolecular coupling reactions5 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (4-trifluoromethylbenzoyl)acetate used for?
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Ethyl (4-trifluoromethylbenzoyl)acetate is used as a reactant in various chemical syntheses, including In-catalyzed cycloisomerisation, chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water, Guanidine-catalyzed enantioselective Michael reactions, transesterification reactions, and intermolecular coupling reactions.
What are the CAS number and chemical formula for Ethyl (4-trifluoromethylbenzoyl)acetate?
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The CAS number is 106263-53-0 and the linear formula is CF<sub>3</sub>C<sub>6</sub>H<sub>4</sub>COCH<sub>2</sub>CO<sub>2</sub>C<sub>2</sub>H<sub>5</sub>.
What grade and purity does Tech Serve Solutions supply for Ethyl (4-trifluoromethylbenzoyl)acetate?
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Tech Serve Solutions supplies this chemical for research and development purposes. The exact grade and purity are available on the Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should Ethyl (4-trifluoromethylbenzoyl)acetate be handled safely?
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When handling Ethyl (4-trifluoromethylbenzoyl)acetate, appropriate personal protective equipment, including eyeshields and gloves, should be worn. The compound is classified under WGK Germany 3, indicating it is hazardous to water. Please consult the Safety Data Sheet for comprehensive handling information.
Is Ethyl (4-trifluoromethylbenzoyl)acetate a controlled substance?
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Based on the provided data, there is no indication that Ethyl (4-trifluoromethylbenzoyl)acetate is a controlled substance.
How is Ethyl (4-trifluoromethylbenzoyl)acetate packed, shipped, and exported?
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Ethyl (4-trifluoromethylbenzoyl)acetate is carefully packed to ensure stability during transit and is available for export globally. Specific packaging details depend on order size and destination.
How can I request a sample or quote for Ethyl (4-trifluoromethylbenzoyl)acetate?
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To request a sample or a quote for Ethyl (4-trifluoromethylbenzoyl)acetate, please contact our sales department through the website or via email, providing your specific requirements.
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