Ethyl 3-amino-4,4,4-trifluorocrotonate
Ethyl 3-amino-4,4,4-trifluorocrotonate (CAS 372-29-2) is a specialised organic building block with the linear formula CF₃C(NH₂)=CHCO₂C₂H₅ and a molecular weight of 183.13 g/mol. This fluorinated ester is primarily utilised in chemical synthesis for the preparation of complex heterocyclic compounds, including novel perfluoroalkyl-substituted pyrazoles and bis(trifluoromethyl)pyridine carboxylates. It is supplied by Tech Serve Solutions for research and development purposes.
- IUPAC
- Ethyl 3-amino-4,4,4-trifluoro-2-butenoate
- Synonyms
- 372-29-2CF3C(NH2)=CHCO2C2H5Ethyl 3-amino-4,4,4-trifluoro-2-butenoate
Synthesis of Fluorinated Heterocycles
Ethyl 3-amino-4,4,4-trifluorocrotonate serves as a key intermediate in the synthesis of various fluorinated heterocyclic compounds. It is particularly valuable for the preparation of novel perfluoroalkyl-substituted pyrazoles.
Preparation of Pyridine Derivatives
This compound is employed in the synthesis of bis(trifluoromethyl)pyridine carboxylates. Its trifluoromethyl group and reactive functional groups allow for the construction of complex pyridine structures.
Organic Synthesis Building Block
As a versatile organic building block, Ethyl 3-amino-4,4,4-trifluorocrotonate is useful in advanced organic synthesis. It provides a convenient route to introduce trifluoromethylated moieties into target molecules.
| Molecular weight | 183.13 |
|---|---|
| Linear formula | CF3C(NH2)=CHCO2C2H5 |
| Assay | 96% |
| Boiling point | 83 °C/15 mmHg(lit.) |
| Density | 1.245 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.424(lit.) |
| Application | Employed in the preparation of novel perfluoroalkyl-substituted pyrazoles,1 and bis(trifluoromethyl)pyridine carboxylates.2 |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 65 °C / 149 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl 3-amino-4,4,4-trifluorocrotonate used for?
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Ethyl 3-amino-4,4,4-trifluorocrotonate is used as a building block in organic synthesis, particularly for the preparation of novel perfluoroalkyl-substituted pyrazoles and bis(trifluoromethyl)pyridine carboxylates.
What is the CAS number and formula for Ethyl 3-amino-4,4,4-trifluorocrotonate?
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The CAS number is 372-29-2 and the linear formula is CF₃C(NH₂)=CHCO₂C₂H₅.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl 3-amino-4,4,4-trifluorocrotonate with an assay of 96%. This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling precautions for this chemical?
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Ethyl 3-amino-4,4,4-trifluorocrotonate is classified as a GHS07 Warning substance. It is harmful if swallowed, in contact with skin, and if inhaled, and causes serious eye irritation and may cause respiratory irritation (H302, H312, H319, H332, H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals in compliance with all relevant international regulations to ensure safe transit.
How can I request a sample or quote?
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To request a sample or a quote for Ethyl 3-amino-4,4,4-trifluorocrotonate, please contact our sales team through the website or by phone.
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