Ethyl 2-methyl-3-indoleacetate
Ethyl 2-methyl-3-indoleacetate (CAS 21909-49-9) is a chemical compound with the molecular formula C13H15NO2 and a molecular weight of 217.26 g/mol. This indole derivative serves as a valuable building block in organic synthesis. It is primarily utilised as a reactant in the preparation of compounds with potential biological activities, including HDAC inhibitors and receptor antagonists. Its structural features make it a useful intermediate in complex chemical syntheses.
- IUPAC
- 2-methylindole-3-acetic acid,NSC 289352
- Synonyms
- 2-methylindole-3-acetic acid ethyl ester
Preparation of HDAC Inhibitors
Ethyl 2-methyl-3-indoleacetate is employed as a reactant in the synthesis of hydroxamate derivatives. These derivatives have demonstrated potential as histone deacetylase (HDAC) inhibitors, indicating utility in anticancer research and development.
Synthesis of Gastrin/CCK-B Receptor Antagonists
This compound serves as a key reactant in the stereoselective preparation of AG-041R. AG-041R is recognised as a potent gastrin and cholecystokinin B (CCK-B) receptor antagonist, relevant in pharmacological research.
Heterocyclic Building Block
As an indole derivative, Ethyl 2-methyl-3-indoleacetate functions as a versatile heterocyclic building block. It is suitable for incorporation into more complex molecular structures within chemical synthesis endeavours.
| Molecular weight | 217.26 |
|---|---|
| Empirical formula | C13H15NO2 |
| Assay | 98% |
| Boiling point | 195-196 °C/3.5 mmHg(lit.) |
| Density | 1.11 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.571(lit.) |
| Application | • Reactant for preparation of hydroxamate derivatives as HDAC inhibitor with anticancer activity1• Reactant for stereoselective preparation of AG-041R, as a Potent Gastrin/CCK-B Receptor Antagonist2 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl 2-methyl-3-indoleacetate used for?
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Ethyl 2-methyl-3-indoleacetate is used as a reactant in the preparation of hydroxamate derivatives with potential anticancer activity and in the stereoselective synthesis of AG-041R, a gastrin/CCK-B receptor antagonist. It also serves as a heterocyclic building block in chemical synthesis.
What are the CAS number and molecular formula?
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The CAS number for Ethyl 2-methyl-3-indoleacetate is 21909-49-9 and its molecular formula is C13H15NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl 2-methyl-3-indoleacetate with an assay of 98%. This product is suitable for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should Ethyl 2-methyl-3-indoleacetate be handled safely?
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Ethyl 2-methyl-3-indoleacetate is a Warning substance (GHS07) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, should be used when handling this chemical.
How is this chemical exported and shipped?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and reagents, including Ethyl 2-methyl-3-indoleacetate. We adhere to all international shipping and export regulations for chemical products.
How can I request a sample or quote?
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To request a sample or a quote for Ethyl 2-methyl-3-indoleacetate, please contact our sales team via the website or email, providing your specific requirements.
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