Ethyl 2-fluoroacetoacetate
Ethyl 2-fluoroacetoacetate (CAS: 1522-41-4) is a fluorinated organic building block with the linear formula CH3COCH(F)CO2C2H5 and a molecular weight of 148.13 g/mol. This compound is valuable in organic synthesis, particularly in reactions involving stereoselective transformations and the construction of complex fluorinated molecules. Its utility is demonstrated in various catalytic processes, contributing to advancements in synthetic chemistry.
- IUPAC
- 2-Fluoro-3-oxobutanoic acid ethyl ester,Ethyl 2-fluoro-3-oxobutanoate,Ethyl 2-fluoro-3-oxobutyrate,NSC 24563
- Synonyms
- 2-Fluoro-3-oxobutanoic acid ethyl esterEthyl 2-fluoro-3-oxobutanoateEthyl 2-fluoro-3-oxobutyrateNSC 24563
Michael Addition Reactions
Serves as a key reactant in Michael addition-induced cyclization reactions, facilitating the formation of cyclic structures with specific stereochemical outcomes. Its fluorinated nature can influence the reactivity and properties of the resulting products.
Asymmetric Synthesis
Employed in asymmetric Mannich reactions, a crucial transformation for creating chiral beta-amino carbonyl compounds. This application highlights its role in stereoselective synthesis for complex molecule construction.
Organocatalytic Conjugate Addition
Utilised in enantioselective organocatalytic conjugate addition reactions, where it acts as an electrophilic partner. This enables the synthesis of chiral fluorinated compounds with high enantiomeric purity.
| Molecular weight | 148.13 |
|---|---|
| Linear formula | CH3COCH(F)CO2C2H5 |
| Boiling point | 183 °C(lit.) |
| Density | 1.181 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.414(lit.) |
| Application | Reactant for:• Michael addition-induced cyclization reaction1• Asymmetric Mannich reaction2• Enantioselective organocatalytic conjugate addition3 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 90 °C / 194 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl 2-fluoroacetoacetate used for?
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Ethyl 2-fluoroacetoacetate is used as a reactant in Michael addition-induced cyclization, asymmetric Mannich reactions, and enantioselective organocatalytic conjugate addition, serving as a versatile fluorinated building block in organic synthesis.
What are the CAS number and chemical formula for Ethyl 2-fluoroacetoacetate?
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The CAS number for Ethyl 2-fluoroacetoacetate is 1522-41-4. Its linear formula is CH3COCH(F)CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions typically supplies Ethyl 2-fluoroacetoacetate as a research or technical grade material. The specific assay/purity can be found on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Ethyl 2-fluoroacetoacetate be handled safely?
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Ethyl 2-fluoroacetoacetate is a warning substance (GHS07) and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Always wear appropriate personal protective equipment, including eyeshields and gloves, and ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling instructions.
How is Ethyl 2-fluoroacetoacetate packed, shipped, and exported?
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Ethyl 2-fluoroacetoacetate is packed according to standard chemical shipping regulations to ensure safe transport. Tech Serve Solutions, a global supplier and exporter, handles all necessary documentation for international shipments.
How can I request a sample or a quote for Ethyl 2-fluoroacetoacetate?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number (1522-41-4).
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