Ethanesulfonyl chloride
Ethanesulfonyl chloride (CAS 594-44-5), with the linear formula CH3CH2SO2Cl and a molecular weight of 128.58 g/mol, is a chemical compound utilised in organic synthesis. Its primary function is as an ethylating agent and in the preparation of sulfonamides and other sulfur-containing organic molecules. This reagent is valued for its reactivity in introducing the ethylsulfonyl group into various substrates.
Organic Synthesis Reagent
Ethanesulfonyl chloride serves as a key reagent in the synthesis of complex organic molecules. It is employed for the introduction of the ethylsulfonyl moiety (CH3CH2SO2-) through reactions with nucleophiles such as amines and alcohols.
Protecting Group Chemistry
It can be used in the protection of functional groups, particularly in the derivatisation of alcohols and amines to form sulfonates and sulfonamides, respectively. This temporary modification facilitates subsequent reaction steps.
Pharmaceutical Intermediate Synthesis
The compound finds application in the multi-step synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its reactivity allows for the construction of specific molecular architectures required in drug discovery and development.
Derivatisation for Analysis
Ethanesulfonyl chloride can be used to derivatise certain analytes, enhancing their detectability or separability in analytical techniques like chromatography.
| Molecular weight | 128.58 |
|---|---|
| Linear formula | CH3CH2SO2Cl |
| Assay | ≥98.0% (AT) |
| Boiling point | 177 °C(lit.) |
| Density | 1.357 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.452(lit.)n20/D 1.453 |
Hazard statements
- H302Harmful if swallowed
- H310Fatal in contact with skin
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 83 °C / 181.4 °F |
| Transport (UN / ADR) | UN 2927 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 21/22-23-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethanesulfonyl chloride used for?
+
Ethanesulfonyl chloride is used as a reagent in organic synthesis, particularly for introducing the ethylsulfonyl group. It is also employed in protecting group chemistry, the synthesis of pharmaceutical intermediates, and for derivatisation in analytical chemistry.
What is the CAS number and formula for Ethanesulfonyl chloride?
+
The CAS number for Ethanesulfonyl chloride is 594-44-5, and its linear formula is CH3CH2SO2Cl.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Ethanesulfonyl chloride with an assay of ≥98.0% (AT). We do not represent this product as USP, BP, or EP grade.
How should Ethanesulfonyl chloride be handled safely?
+
Ethanesulfonyl chloride is a dangerous substance. It is harmful if swallowed, causes severe skin burns and eye damage, and is toxic if inhaled. Always handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, in a well-ventilated area. Consult the Safety Data Sheet (SDS) for full details.
Is Ethanesulfonyl chloride a controlled substance?
+
The provided data does not indicate that Ethanesulfonyl chloride is a controlled substance.
How can I request a quote or sample?
+
To request a quote or a sample of Ethanesulfonyl chloride, please contact our sales team via the website or your designated account manager.
How is Ethanesulfonyl chloride shipped?
+
Ethanesulfonyl chloride is shipped according to UN 2927, Class 6.1, Packing Group II regulations, indicating it is transported as a toxic liquid.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis