Esmolol hydrochloride
Esmolol hydrochloride (CAS 81161-17-3), with the empirical formula C16H26NClO4 and a molecular weight of 331.83 g/mol, is a potent and selective beta-1 adrenergic receptor antagonist. This cardioselective beta-blocker is primarily recognised for its rapid onset and short duration of action. It is widely employed in critical care settings for the management of tachyarrhythmias and perioperative hypertension, owing to its precise titration capabilities.
- IUPAC
- 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride
- Synonyms
- 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride
Cardiovascular Therapeutics
Esmolol hydrochloride is a critical therapeutic agent for managing supraventricular tachycardias, including atrial fibrillation and atrial flutter. Its cardioselectivity allows for effective rate control with a reduced risk of bronchospasm compared to non-selective beta-blockers.
Perioperative Management
This compound is extensively used to control heart rate and blood pressure during and after surgical procedures. Its predictable pharmacokinetic profile facilitates rapid dose adjustments, essential for maintaining haemodynamic stability in surgical patients.
Critical Care Settings
In intensive care units, esmolol hydrochloride is vital for treating acute tachyarrhythmias and hypertensive emergencies. Its rapid metabolism and short half-life ensure swift termination of effect upon discontinuation, which is crucial in unstable patients.
Research in Cardiovascular Physiology
As a well-characterised beta-1 selective antagonist, esmolol hydrochloride serves as a valuable tool in research laboratories studying adrenergic receptor function and cardiovascular physiology. It allows for precise investigation into the role of beta-1 receptors in various physiological and pathological processes.
| Molecular weight | 331.83 |
|---|---|
| Empirical formula | C16H26NClO4 |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | H2O: soluble12 mg/mL |
| Storage temperature | 2-8°C |
| Melting point | 89.0-90.6 °C |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 52/53 |
| Safety statements (S) | 61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Esmolol hydrochloride used for?
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Esmolol hydrochloride is primarily used for the management of rapid heart rates (tachyarrhythmias) and hypertension, particularly in critical care and perioperative settings, due to its rapid onset and short duration of action.
What are the CAS number and formula for Esmolol hydrochloride?
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The CAS number for Esmolol hydrochloride is 81161-17-3, and its empirical formula is C16H26NClO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Esmolol hydrochloride with a purity of ≥98% (HPLC). We do not represent this product as meeting specific pharmacopoeia standards such as USP, BP, or EP unless explicitly stated. For critical applications, customers should verify suitability.
How should Esmolol hydrochloride be handled and stored?
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Esmolol hydrochloride is labelled with a GHS07 symbol and a Warning signal word, indicating it can cause serious eye irritation (H319). It should be handled with eyeshields and gloves, stored at 2-8°C, and kept away from water sources for dissolution (soluble in water: 12 mg/mL). Dispose of contents/container in accordance with local regulations (Safety statements Europe: 61).
Is Esmolol hydrochloride a controlled substance?
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The provided data does not indicate that Esmolol hydrochloride is a controlled substance. However, users should always consult relevant national and international regulations.
How is Esmolol hydrochloride packed and shipped?
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Esmolol hydrochloride is typically supplied as a solid. Packaging and export procedures adhere to international shipping regulations for chemical compounds, ensuring product integrity and compliance.
How can I request a sample or quote for Esmolol hydrochloride?
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To request a sample or quote, please use the contact form on our website or reach out to our sales department directly. Provide the product name and CAS number (81161-17-3) for prompt service.
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