Elacridar

CAS 143664-11-3C34H33N3O5Cell Biology

Elacridar (CAS: 143664-11-3), with the molecular formula C34H33N3O5 and a molecular weight of 563.64 g/mol, is a white to beige powder. This compound functions as a potent inhibitor of P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). It is a valuable tool in cell biology research, particularly for studying multi-drug resistance (MDR) and its modulation, aiding in investigations of drug efflux pumps and cellular drug metabolism.

IUPAC: GF120918,GG918,GW0918,N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
Synonyms: GF120918GG918GW0918N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide

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Elacridar (C34H33N3O5) — chemical structure, CAS 143664-11-3; Life Science, fine chemical supplied by Tech Serve Solutions

Cell BiologyDrug Efflux PumpsMulti-Drug Resistance

01 /Applications

Inhibition of Drug Efflux Pumps

Elacridar is widely used as an inhibitor of P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). This allows researchers to investigate the role of these efflux pumps in multidrug resistance (MDR) phenomena within cellular systems.

Enhancing Drug Efficacy Studies

By blocking MDR transporters, Elacridar can be employed to assess the potential of co-administered drugs to overcome resistance mechanisms. This is crucial for understanding drug pharmacokinetics and developing more effective therapeutic strategies.

Cellular Drug Metabolism Research

This compound serves as a research tool for exploring the complexities of cellular drug metabolism and transport. Its specific inhibitory action helps elucidate pathways affected by MDR transporters.

Neuroscience and Cell Signaling Investigations

Elacridar finds application in cell signaling and neuroscience research where the activity of drug efflux pumps may influence neuronal function or drug distribution in the central nervous system.

02 /Properties

Molecular weight	563.64
Empirical formula	C34H33N3O5
Assay	≥98% (HPLC)
Form	powder
Colour	white to beige
Solubility	DMSO: soluble2 mg/mL (clear solution, warmed)
Storage temperature	−20°C

03 /Identifiers & registry

CAS number

143664-11-3

04 /Additional specifications

Shipped In	wet ice

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Elacridar used for?

Elacridar is used as a research tool to inhibit P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), aiding in the study of multi-drug resistance (MDR), drug efflux pumps, and cellular drug metabolism. It is also used in cell signaling and neuroscience research.

What is the CAS number and molecular formula for Elacridar?

The CAS number for Elacridar is 143664-11-3, and its molecular formula is C34H33N3O5.

What grade and purity does Tech Serve Solutions supply for Elacridar?

Tech Serve Solutions supplies Elacridar with a purity of ≥98% (HPLC). This is a research grade chemical, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.

How should Elacridar be handled and stored?

Elacridar is classified under WGK Germany 2, indicating it is hazardous to water. It should be stored at -20°C. Handle with appropriate personal protective equipment in a well-ventilated area.

How is Elacridar shipped?

Elacridar is shipped in wet ice to maintain its stability during transit.

How can I request a quote or sample for Elacridar?

To request a quote or sample of Elacridar, please contact the TSS sales team via our website or direct email, providing your specific requirements and shipping details.