DL-tert-Leucine
DL-tert-Leucine (CAS: 33105-81-6) is a non-proteinogenic amino acid with the linear formula (CH3)3CCH(NH2)COOH and a molecular weight of 131.17 g/mol. This chiral compound is primarily utilised in chemical biology and synthesis, particularly in the development of peptide chemistry and unnatural amino acid derivatives. Tech Serve Solutions supplies DL-tert-Leucine with a high purity of 98%, supporting research and development activities.
- IUPAC
- (±)-2-Amino-3,3-dimethylbutyric acid,DL-α-tert-Butylglycine

Peptide Synthesis
DL-tert-Leucine serves as a valuable building block in the synthesis of peptides, particularly for creating sterically hindered or unnatural peptide sequences. Its bulky tert-butyl side chain can influence peptide conformation and stability.
Chemical Biology Research
As an unnatural amino acid derivative, it is employed in chemical biology to probe protein structure-function relationships or to create novel biomolecules. It allows researchers to introduce non-natural structural motifs into biological systems.
Organic Synthesis Intermediate
The compound acts as an intermediate in various organic synthesis pathways. Its unique structure makes it useful for constructing complex organic molecules and chiral compounds.
Drug Discovery and Development
DL-tert-Leucine can be incorporated into potential drug candidates to modify their pharmacokinetic properties, such as metabolic stability or receptor binding affinity. Its inclusion may lead to novel therapeutic agents.
| Molecular weight | 131.17 |
|---|---|
| Linear formula | (CH3)3CCH(NH2)COOH |
| Assay | 98% |
| Melting point | >300 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is DL-tert-Leucine used for?
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DL-tert-Leucine is primarily used in chemical biology and synthesis, particularly in peptide chemistry and as an unnatural amino acid derivative. It also serves as an intermediate in organic synthesis and finds applications in drug discovery.
What is the CAS number and formula for DL-tert-Leucine?
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The CAS number for DL-tert-Leucine is 33105-81-6. Its linear formula is (CH3)3CCH(NH2)COOH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies DL-tert-Leucine with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product data.
How should DL-tert-Leucine be handled safely?
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Handling DL-tert-Leucine requires appropriate personal protective equipment, including eyeshields and gloves. A respirator filter of type N95 (US) or P1 (EN143) is recommended. Refer to the Safety Data Sheet for comprehensive handling information.
Is DL-tert-Leucine a controlled substance?
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The provided data does not indicate that DL-tert-Leucine (CAS: 33105-81-6) is a controlled substance.
How is DL-tert-Leucine packed, shipped, and exported?
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Tech Serve Solutions adheres to strict international shipping regulations for the packing and export of chemicals like DL-tert-Leucine, ensuring safe and compliant delivery worldwide.
How can I request a sample or quote for DL-tert-Leucine?
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To request a sample or a quotation for DL-tert-Leucine, please contact our sales team via the website or direct email, providing your specific requirements.
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