Diphenhydramine hydrochloride
Diphenhydramine hydrochloride (CAS 147-24-0), with the molecular formula C17H21NO · HCl and a molecular weight of 291.82, is a well-known compound primarily recognised for its antihistamine properties. It acts as an H1 receptor antagonist. This chemical is widely employed in research settings for studies related to histamine signalling and receptor interactions, and it serves as a valuable reagent in biochemical and cell biology investigations.
- IUPAC
- 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride,N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride
- Synonyms
- 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochlorideN-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

Histamine Receptor Research
Diphenhydramine hydrochloride is frequently used as a tool compound in pharmacological research to study the function and blockade of histamine H1 receptors. Its role as an antagonist aids in understanding antihistaminergic mechanisms.
Biochemical Assays
This compound serves as a valuable reagent in various biochemical assays. Researchers utilise it to investigate cellular responses and signalling pathways involving histamine and related receptors.
Cell Biology Studies
In cell biology, Diphenhydramine hydrochloride can be employed to probe cellular functions influenced by histamine signalling. It aids in characterising cell behaviour and responses in experimental models.
Neuroscience Research
As a compound affecting neurotransmitter systems indirectly, it finds application in neuroscience research, particularly in studies involving neuronal signalling pathways and receptor pharmacology.
| Molecular weight | 291.82 |
|---|---|
| Empirical formula | C17H21NO · HCl |
| Assay | ≥98% (HPLC) |

Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... HRH1(3269) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diphenhydramine hydrochloride used for?
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Diphenhydramine hydrochloride (CAS 147-24-0) is primarily used in research as an H1 receptor antagonist for studies in pharmacology, biochemistry, cell biology, and neuroscience. It is a valuable tool for investigating histamine signalling pathways.
What are the CAS number and formula for Diphenhydramine hydrochloride?
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The CAS number for Diphenhydramine hydrochloride is 147-24-0, and its molecular formula is C17H21NO · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diphenhydramine hydrochloride with an assay of ≥98% (HPLC). This product is intended for research and laboratory use; TSS does not represent it as USP, BP, or EP grade.
What are the safety and handling recommendations for Diphenhydramine hydrochloride?
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Diphenhydramine hydrochloride is classified as harmful if swallowed (H302) and requires appropriate handling. Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, faceshields, and gloves. Always consult the Safety Data Sheet (SDS) before use.
How is Diphenhydramine hydrochloride packed, shipped, and exported?
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Diphenhydramine hydrochloride is carefully packed to ensure stability during transit and is available for global export by Tech Serve Solutions. Specific packaging details are available upon request.
How can I request a sample or quote for Diphenhydramine hydrochloride?
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To request a sample or a quote for Diphenhydramine hydrochloride, please contact the Tech Serve Solutions sales team through our website or by phone.
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