Dimethyl sulfate
Dimethyl sulfate (CAS 77-78-1), with the linear formula (CH3O)2SO2 and a molecular weight of 126.13 g/mol, is a powerful methylating agent used extensively in chemical synthesis. Its potent reactivity makes it valuable for introducing methyl groups into various organic compounds. Available from Tech Serve Solutions in a 'puriss. p.a.' grade with an assay of ≥99.8%, it serves as a critical reagent for alkylation reactions in research and industrial applications.
- IUPAC
- Sulfuric acid dimethyl ester
- Synonyms
- Sulfuric acid dimethyl esterMethyl sulfateDMS

Methylation Agent
Dimethyl sulfate is a primary reagent for the methylation of nucleophilic substrates, including alcohols, phenols, amines, and thiols. This process is fundamental in synthesizing a wide array of organic chemicals and pharmaceutical intermediates.
Chemical Synthesis
It is employed in the formation of C-X bonds (non-halogen) and serves as a versatile synthetic reagent in organic chemistry laboratories. Its high reactivity facilitates various transformations crucial for complex molecule construction.
Analytical Chemistry
As an analytical reagent, Dimethyl sulfate is used in specific analytical procedures and chromatography applications. Its defined purity ensures reliable performance in sensitive analytical methods.
| Molecular weight | 126.13 |
|---|---|
| Linear formula | (CH3O)2SO2 |
| Assay | ≥99.8% |
| Grade | puriss. p.a. |
| Boiling point | 188 °C(lit.) |
| Density | 1.333 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.386(lit.) |
| Melting point | −32 °C(lit.) |
| Vapour pressure | 0.7 mmHg (25 °C) |
| Vapour density | 4.3 (vs air) |
| Autoignition temp | 923 °F |



Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
- H317May cause an allergic skin reaction
- H330Fatal if inhaled
- H341Suspected of causing genetic defects
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 83 °C / 181.4 °F |
| Transport (UN / ADR) | UN 1595 6.1/PG 1 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 45-25-26-34-43-68 |
| Safety statements (S) | 53-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dimethyl sulfate primarily used for?
+
Dimethyl sulfate is primarily used as a powerful methylating agent in chemical synthesis for introducing methyl groups into organic compounds, and also finds applications as an analytical reagent.
What is the CAS number and chemical formula for Dimethyl sulfate?
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The CAS number for Dimethyl sulfate is 77-78-1, and its linear chemical formula is (CH3O)2SO2.
What grade and purity does Tech Serve Solutions supply for Dimethyl sulfate?
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Tech Serve Solutions supplies Dimethyl sulfate in a 'puriss. p.a.' grade with an assay of ≥99.8%.
What are the primary safety concerns when handling Dimethyl sulfate?
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Dimethyl sulfate is a highly hazardous substance, classified as toxic if swallowed, causes severe skin burns and eye damage, may cause an allergic skin reaction, is fatal if inhaled, and is suspected of causing genetic defects and cancer. Strict adherence to safety protocols, including appropriate personal protective equipment and ventilation, is essential.
How is Dimethyl sulfate packed, shipped, and exported by TSS?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures Dimethyl sulfate is packed, shipped, and exported in compliance with all relevant international regulations for hazardous materials.
How can I request a quote or sample for Dimethyl sulfate?
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To request a quote or sample for Dimethyl sulfate, please contact the Tech Serve Solutions sales team through our website or direct contact details.
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