Diethyl 4-methoxybenzylphosphonate
Diethyl 4-methoxybenzylphosphonate (CAS: 1145-93-3), with the linear formula CH3OC6H4CH2P(O)(OC2H5)2 and a molecular weight of 258.25 g/mol, is a valuable reagent in organic synthesis. It primarily functions as a C-C bond forming agent, particularly in Horner-Wadsworth-Emmons reactions for the olefination of aldehydes and ketones. This compound facilitates the synthesis of complex molecules, including biologically active stilbenoids and their derivatives.
- IUPAC
- [(4-Methoxyphenyl)methyl]phosphonic acid diethyl ester
- Synonyms
- [(4-Methoxyphenyl)methyl]phosphonic acid diethyl ester
Synthesis of γ-Monofluorinated Goniothalamin Analogs
Serves as a key reactant in the ring-opening hydrofluorination process to create γ-monofluorinated goniothalamin analogs, contributing to medicinal chemistry research.
Preparation of Stilbenoid Derivatives
Utilised in the synthesis of stilbenoid compounds exhibiting neuroprotective activities, offering pathways for developing new therapeutic agents.
Generation of Resveratrol Hybrids
Employed in constructing resveratrol-chroman hybrids with significant antioxidant properties, relevant for nutraceutical and pharmaceutical development.
Oligostilbenoid Synthesis
Facilitates the regioselective cyclodehydration and arylation steps required for the formation of complex oligostilbenoids.
Synthesis of Resveratrol Fatty Alcohols
A reactant in the preparation of resveratrol fatty alcohols, which have demonstrated effects on neural stem cell differentiation and neuroinflammation modulation.
| Molecular weight | 258.25 |
|---|---|
| Linear formula | CH3OC6H4CH2P(O)(OC2H5)2 |
| Assay | ≥98% |
| Boiling point | 155 °C/0.5 mmHg(lit.) |
| Density | 1.5 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.504(lit.) |
| Application | Reactant for synthesis of: • γ -Monofluorinated goniothalamin analogs via ring-opening hydrofluorination1• Stilbenoid derivatives with neuroprotective activity2,3• Resveratrol-chroman hybrids with antioxidant activity4• Oligostilbenoids using regioselective cyclodehydration and arylation5• Resveratrol fatty alcohols with effects on differentiation of neural stem cells and modulation of neuroinflammation6 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl 4-methoxybenzylphosphonate used for?
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Diethyl 4-methoxybenzylphosphonate (CAS: 1145-93-3) is primarily used as a reactant in organic synthesis, particularly for C-C bond formation via the Horner-Wadsworth-Emmons reaction to produce olefins, and in the synthesis of various biologically active compounds like stilbenoids and their derivatives.
What are the CAS number and formula for Diethyl 4-methoxybenzylphosphonate?
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The CAS number is 1145-93-3, and the linear formula is CH3OC6H4CH2P(O)(OC2H5)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl 4-methoxybenzylphosphonate with an assay of ≥98%. This product is supplied for research and laboratory use; TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
What are the safety considerations when handling Diethyl 4-methoxybenzylphosphonate?
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Diethyl 4-methoxybenzylphosphonate is a combustible liquid with a flash point of 110 °C (230 °F). Handling requires appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (half-mask respirator or multi-purpose combination respirator cartridge). Ensure adequate ventilation and avoid exposure to heat, sparks, and open flames. Consult the Safety Data Sheet for full details.
How is Diethyl 4-methoxybenzylphosphonate packed, shipped, and exported?
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Diethyl 4-methoxybenzylphosphonate is carefully packaged to ensure safe transit and is available for export globally through Tech Serve Solutions' established logistics network.
How can I request a sample or quote for Diethyl 4-methoxybenzylphosphonate?
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To request a sample or a quotation for Diethyl 4-methoxybenzylphosphonate, please contact our sales team via the website or direct email, specifying your requirements.
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