Dichlorobis(trimethylphosphine)nickel(II)

CAS 19232-05-4[((CH3)3P)]2NICl2Catalysis & Inorganic

Dichlorobis(trimethylphosphine)nickel(II) (CAS 19232-05-4), with the linear formula [((CH3)3P)]2NICl2, is a nickel(II) complex with a molecular weight of 281.75 g/mol. Supplied at 97% purity, this compound serves as a valuable catalyst in various organic synthesis reactions, including cross-coupling, cycloaddition, and arylation processes. Its specific coordination environment makes it effective in facilitating challenging bond formations in complex molecules.

IUPAC: Bis(trimethylphosphine)nickel dichloride
Synonyms: Bis(trimethylphosphine)nickel dichloride

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Dichlorobis(trimethylphosphine)nickel(II) ([((CH3)3P)]2NICl2) — chemical structure, CAS 19232-05-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisNickel

01 /Applications

Wenkert Arylation Catalyst

This nickel complex catalyses the Wenkert arylation of thiophene using aryl Grignard reagents. It is also employed in the Kumada-Corriu cross-coupling of Grignard reagents, showcasing its utility in C-C bond formation.

Cycloaddition Reactions

It facilitates regioselective [2+2+2] cycloaddition of carboryne with alkynes, yielding benzocarborane compounds. This application is key in constructing specific carbocyclic frameworks.

Borylation and Cyanation Catalyst

The compound catalyses the borylation of aryl chlorides, an important method for introducing boron functionalities. Additionally, it is used in the arylcyanation of alkynes via C-C bond activation.

Reductive Cyclization

Dichlorobis(trimethylphosphine)nickel(II) is instrumental in reductive aldol cyclization-lactonization reactions, enabling the formation of complex lactone structures.

02 /Properties

Molecular weight	281.75
Linear formula	[((CH3)3P)]2NICl2
Assay	97%
Application	Catalyst for:• Wenkert arylation of thiophene with aryl Grignard reagents1• Regioselective [2+2+2] cycloaddition of carboryne with alkynes to give benzocarborane compounds2• Kumada-Corriu cross coupling of Grignard reagents3• Borylation of aryl chlorides4• Reductive aldol cyclization-lactonization5• Arylcyanation of alkynes6• Alkynylation of benzonitriles via C-C bond activation7
Melting point	194-199 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	20/21/22
Safety statements (S)	36/37

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

19232-05-4

MDL number

MFCD03412128

PubChem substance

24880384

05 /Additional specifications

Absorption	244 nm

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Dichlorobis(trimethylphosphine)nickel(II) used for?

Dichlorobis(trimethylphosphine)nickel(II) is used as a catalyst in various organic synthesis reactions, including Wenkert arylation, regioselective [2+2+2] cycloaddition, Kumada-Corriu cross-coupling, borylation of aryl chlorides, reductive aldol cyclization-lactonization, arylcyanation of alkynes, and alkynylation of benzonitriles.

What are the CAS number and formula for Dichlorobis(trimethylphosphine)nickel(II)?

The CAS number is 19232-05-4 and the linear formula is [((CH3)3P)]2NICl2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Dichlorobis(trimethylphosphine)nickel(II) at a purity of 97%. TSS does not represent this product as USP, BP, EP, or any pharmacopoeia grade.

How should Dichlorobis(trimethylphosphine)nickel(II) be handled safely?

Dichlorobis(trimethylphosphine)nickel(II) is classified as harmful if swallowed, in contact with skin, or if inhaled (H302-H312-H332). Appropriate personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area and avoid dust formation.

How is Dichlorobis(trimethylphosphine)nickel(II) packed and shipped?

Dichlorobis(trimethylphosphine)nickel(II) is carefully packed according to international shipping regulations and is available for export globally by Tech Serve Solutions.

How can I request a quote or sample?

To request a quote or sample of Dichlorobis(trimethylphosphine)nickel(II), please contact our sales team through the website or by phone, providing your specific requirements.