D-tert-Leucine
D-tert-Leucine (CAS: 26782-71-8), a non-proteinogenic amino acid, is a valuable chiral building block in organic synthesis. With a molecular weight of 131.17 g/mol and an assay of 98%, it plays a crucial role in the development of novel pharmaceuticals and in peptide chemistry. Its unique structure makes it an important intermediate for creating complex molecules and unnatural peptides with tailored properties.
- IUPAC
- (R)-2-Amino-3,3-dimethylbutyric acid,D-α-tert-Butylglycine
- Synonyms
- (R)-2-Amino-3,3-dimethylbutyric acidD-α-tert-Butylglycine
Chiral Synthesis
D-tert-Leucine serves as a chiral auxiliary and building block in asymmetric synthesis, enabling the stereoselective creation of complex organic molecules. Its rigid structure is particularly useful in constructing sterically hindered intermediates.
Peptide Chemistry
Incorporated into peptide sequences, this unnatural amino acid can impart unique conformational properties or resistance to enzymatic degradation. It is used in the synthesis of modified peptides for research and therapeutic applications.
Pharmaceutical Intermediates
It functions as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Its chirality is essential for developing enantiomerically pure drugs targeting specific biological pathways.
Chemical Biology Research
D-tert-Leucine is utilized in chemical biology to probe protein structure and function, and to develop novel biologically active compounds. Its incorporation can lead to peptides with altered binding affinities or stability.
| Molecular weight | 131.17 |
|---|---|
| Linear formula | (CH3)3CCH(NH2)CO2H |
| Assay | 98% |
| Optical activity | [α]25/D +9.5°, c = 3% in H2O |
| Melting point | ≥300 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is D-tert-Leucine used for?
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D-tert-Leucine is primarily used as a chiral building block in organic synthesis, for peptide chemistry, as a pharmaceutical intermediate, and in chemical biology research. It is especially valuable for creating unnatural peptides and complex chiral molecules.
What is the CAS number and formula for D-tert-Leucine?
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The CAS number for D-tert-Leucine is 26782-71-8. Its linear formula is (CH3)3CCH(NH2)CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies D-tert-Leucine with an assay of 98%. This product is suitable for research and synthesis purposes. It is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How should D-tert-Leucine be handled safely?
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Handling D-tert-Leucine requires appropriate personal protective equipment, including eyeshields and gloves. A respirator filter suitable for particulates (type N95 or P1) is recommended, and it should be handled in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive guidance.
Is D-tert-Leucine a controlled substance?
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The provided data does not indicate that D-tert-Leucine is a controlled substance.
How is D-tert-Leucine packed and shipped?
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D-tert-Leucine is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations for fine chemicals.
How can I request a quote or sample for D-tert-Leucine?
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To request a quote or a sample of D-tert-Leucine, please use the contact form on our website or contact our sales department directly with your inquiry.
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