Cytochalasin H from Phomopsis sp.
Cytochalasin H (CAS: 53760-19-3), a complex organic molecule with the formula C30H39NO5 and a molecular weight of 493.63 g/mol, is a potent inhibitor of actin polymerisation. Derived from Phomopsis sp., this compound is primarily utilised in biochemical research as a tool to study cellular processes involving the cytoskeleton. Its specific mechanism of action makes it valuable for investigating cell motility, division, and other actin-dependent cellular functions.
Actin Polymerisation Inhibition
Cytochalasin H specifically binds to the barbed end of actin filaments, preventing further polymerisation. This makes it a crucial reagent for researchers studying the dynamics of the cytoskeleton and its role in cellular structure and movement.
Cell Biology Research
As a potent inhibitor of actin, Cytochalasin H is widely employed in cell biology laboratories to dissect cellular mechanisms. It aids in understanding processes such as cell division, cell migration, and phagocytosis, where actin dynamics are critical.
Cytoskeleton Studies
The compound serves as an essential tool for investigating the cytoskeleton, a complex network of proteins that provides cells with mechanical support and organises their contents. Cytochalasin H's ability to disrupt actin filaments allows for detailed analysis of cytoskeletal functions.
Cell Signaling Investigations
By interfering with actin organisation, Cytochalasin H can indirectly affect various cell signaling pathways. Researchers use it to explore the interplay between cytoskeletal rearrangements and signal transduction in different cell types.
| Molecular weight | 493.63 |
|---|---|
| Empirical formula | C30H39NO5 |
| Storage temperature | 2-8°C |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
- H361Suspected of damaging fertility or the unborn child
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 63-26/27/28 |
| Safety statements (S) | 28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Cytochalasin H used for?
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Cytochalasin H (CAS: 53760-19-3) is primarily used in research to inhibit actin polymerisation, serving as a tool to study the cytoskeleton, cell motility, cell division, and related cellular processes.
What are the CAS number and formula for Cytochalasin H?
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The CAS number for Cytochalasin H is 53760-19-3, and its molecular formula is C30H39NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Cytochalasin H as a research-grade chemical. The specific purity is determined by rigorous internal testing. We do not represent this product as USP, BP, or EP grade.
How should Cytochalasin H be handled safely?
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Cytochalasin H is highly toxic and requires careful handling. It is classified as Danger (GHS06, GHS08) with hazard statements including H300 (Fatal if swallowed), H310 (Fatal in contact with skin), and H330 (Fatal if inhaled), and H361 (Suspected of damaging fertility or the unborn child). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (N100 or P3), must be used. Always consult the Safety Data Sheet before use.
How is Cytochalasin H shipped and exported?
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Cytochalasin H is classified under UN 3462, Class 6.1, Packing Group II for transport, indicating its toxic nature. Tech Serve Solutions adheres to all international shipping regulations for hazardous materials and can facilitate global export.
How can I request a sample or quote for Cytochalasin H?
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To request a sample or a quotation for Cytochalasin H, please contact our sales department via the website or direct email, providing your specific requirements and shipping details.
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