Clofarabine

CAS 123318-82-1C10H11ClFN5O3Cell Biology

Clofarabine (CAS 123318-82-1), a purine nucleoside analogue, is a potent cytotoxic agent. It functions by inhibiting DNA synthesis and repair, leading to apoptosis in rapidly dividing cells. This compound is primarily investigated for its anti-cancer properties, particularly in the treatment of certain types of leukemia. Tech Serve Solutions supplies Clofarabine as a high-purity powder for research and development purposes.

IUPAC: (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine

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Clofarabine (C10H11ClFN5O3) — chemical structure, CAS 123318-82-1; Life Science, fine chemical supplied by Tech Serve Solutions

Apoptosis InhibitorsApoptosis and Cell CycleBioactive Small MoleculesCI-CYCell BiologySanofi Aventis More...

01 /Applications

Anti-Cancer Research

Clofarabine is utilized in preclinical studies to investigate its efficacy against various cancer cell lines. Its mechanism of inducing apoptosis makes it a candidate for developing novel chemotherapeutic agents.

Mechanism of Action Studies

Researchers employ Clofarabine to study the intricate pathways of DNA synthesis inhibition and apoptosis induction. Understanding these mechanisms is crucial for developing targeted cancer therapies.

Drug Discovery and Development

As an approved therapeutic agent for specific indications, Clofarabine serves as a reference compound in drug discovery programs aimed at developing related anti-cancer drugs.

02 /Properties

Molecular weight	303.68
Empirical formula	C10H11ClFN5O3
Assay	≥98% (HPLC)
Form	powder
Colour	white
Solubility	DMSO: >10 mg/mL
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash thoroughly after handling
P301IF SWALLOWED

Protective equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 2811 6.1 / PGIII
Water hazard class (WGK, DE)	2
Hazard codes (EU)	T
Risk statements (R)	25
Safety statements (S)	45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

123318-82-1

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Clofarabine used for?

Clofarabine is primarily used in research for its anti-cancer properties, particularly in studying apoptosis induction and its potential as a chemotherapeutic agent.

What are the CAS number and formula for Clofarabine?

The CAS number for Clofarabine is 123318-82-1. Its empirical formula is C10H11ClFN5O3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Clofarabine with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should Clofarabine be handled safely?

Clofarabine is classified as acutely toxic (H300). Handle with extreme caution, using appropriate personal protective equipment including eyeshields, faceshields, gloves, and a P2 respirator. Avoid ingestion.

Is Clofarabine a controlled substance?

The provided data does not indicate that Clofarabine is a controlled substance.

How is Clofarabine packaged and shipped?

Clofarabine is typically supplied as a powder and stored at 2-8°C. It is shipped according to regulations for hazardous materials (UN 2811 6.1 / PGIII).