clasto-Lactacystin β-lactone
clasto-Lactacystin β-lactone (CAS: 154226-60-5), with the molecular formula C10H15NO4 and a molecular weight of 213.23 g/mol, is a potent inhibitor of the proteasome. This bioactive small molecule plays a crucial role in cell biology research, specifically in understanding intracellular protein degradation pathways and cellular signaling. Its ability to selectively inhibit proteasome activity makes it an invaluable tool for investigating various cellular processes and potential therapeutic targets.
Proteasome Inhibition
clasto-Lactacystin β-lactone is widely recognised as a potent inhibitor of the 20S proteasome. It is extensively used in research to block proteasome-dependent protein degradation, allowing scientists to study the effects of protein accumulation on cellular functions and signalling pathways.
Cellular Signaling Studies
By inhibiting the proteasome, this compound helps elucidate the roles of proteasome substrates in various cell signalling cascades. Researchers utilise it to dissect complex cellular processes regulated by protein turnover, including apoptosis and cell cycle control.
Apoptosis Research
The compound's ability to disrupt protein degradation can trigger or modulate apoptotic pathways. It serves as a valuable reagent for investigating the mechanisms of programmed cell death in both normal and disease states.
Biochemical Research Tool
As a well-characterised biochemical, clasto-Lactacystin β-lactone is employed in numerous laboratory settings for its specific inhibitory action. It aids in the characterisation of proteasome function and the identification of novel drug targets.
| Molecular weight | 213.23 |
|---|---|
| Empirical formula | C10H15NO4 |
| Storage temperature | −20°C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is clasto-Lactacystin β-lactone used for?
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clasto-Lactacystin β-lactone is primarily used as a potent inhibitor of the proteasome in biochemical and cell biology research. It is instrumental in studying intracellular protein degradation, cellular signalling, and apoptosis.
What are the CAS number and chemical formula for clasto-Lactacystin β-lactone?
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The CAS number for clasto-Lactacystin β-lactone is 154226-60-5, and its chemical formula is C10H15NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies clasto-Lactacystin β-lactone. The specific grade and purity are available on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should clasto-Lactacystin β-lactone be handled and stored?
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clasto-Lactacystin β-lactone is a dangerous substance. It is toxic if swallowed and causes skin and serious eye irritation, and may cause respiratory irritation (H301-H315-H319-H335). Handle with appropriate personal protective equipment in a well-ventilated area and store at -20°C. Always consult the Safety Data Sheet before use.
Is clasto-Lactacystin β-lactone a controlled substance?
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The provided data does not indicate that clasto-Lactacystin β-lactone is a controlled substance.
How is clasto-Lactacystin β-lactone shipped by Tech Serve Solutions?
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Tech Serve Solutions exports and supplies clasto-Lactacystin β-lactone under strict adherence to international shipping regulations for hazardous materials. UN 2811, Class 6.1, Packing Group III.
How can I request a quote or sample for clasto-Lactacystin β-lactone?
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To request a quote or a sample of clasto-Lactacystin β-lactone, please contact our sales department via the website or direct email, providing your specific requirements.
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