cis-3-Hydroxy-DL-proline
cis-3-Hydroxy-DL-proline (CAS: 4298-05-9; C5H9NO3) is a chiral, non-proteinogenic amino acid derivative with a molecular weight of 131.13 g/mol. Characterised by a hydroxyl group on the 3rd carbon of the pyrrolidine ring, this compound serves as a valuable building block in chemical synthesis. Its primary applications lie within chemical biology and peptide chemistry, where it is incorporated into novel peptide structures and used in the development of specialised molecules.
- IUPAC
- (±)-cis-3-Hydroxypyrrolidine-2-carboxylic acid
- Synonyms
- (±)-cis-3-Hydroxypyrrolidine-2-carboxylic acid

Chemical Synthesis
cis-3-Hydroxy-DL-proline is utilised as a versatile chiral building block in organic synthesis. Its unique structure allows for the introduction of specific stereochemistry and functionalisation into more complex molecules.
Peptide Chemistry
This unnatural amino acid derivative can be incorporated into peptide chains to modify their structure and properties. It is employed in the design and synthesis of peptides with enhanced stability or novel biological activities.
Chemical Biology Research
As a proline derivative, it finds application in chemical biology for probing biological systems or constructing peptidomimetics. It serves as a tool for understanding protein-ligand interactions and developing new therapeutic agents.
| Molecular weight | 131.13 |
|---|---|
| Empirical formula | C5H9NO3 |
| Assay | 95% |
| Melting point | 232 °C (dec.)(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is cis-3-Hydroxy-DL-proline used for?
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cis-3-Hydroxy-DL-proline is primarily used as a building block in chemical synthesis, peptide chemistry, and chemical biology research for the creation of novel molecules and modified peptides.
What are the CAS number and molecular formula of cis-3-Hydroxy-DL-proline?
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The CAS number for cis-3-Hydroxy-DL-proline is 4298-05-9, and its molecular formula is C5H9NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies cis-3-Hydroxy-DL-proline with an assay of 95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should cis-3-Hydroxy-DL-proline be handled?
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Handling cis-3-Hydroxy-DL-proline requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Refer to the safety data sheet for detailed handling instructions.
Is cis-3-Hydroxy-DL-proline a controlled substance?
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The provided data does not indicate that cis-3-Hydroxy-DL-proline (CAS: 4298-05-9) is a controlled substance.
How is cis-3-Hydroxy-DL-proline packed and shipped?
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Tech Serve Solutions packs and ships fine chemicals, pharmaceutical intermediates, and laboratory reagents globally, adhering to all necessary regulations for safe transport.
How can I request a quote or sample for cis-3-Hydroxy-DL-proline?
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To request a quote or sample for cis-3-Hydroxy-DL-proline, please contact our sales team through the TSS website or directly via email or phone.
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