CI-1033
CI-1033 (CAS: 289499-45-2) is a chemical compound with a molecular weight of 558.86 g/mol. Supplied as a solid, this substance finds applications in research, particularly within cell biology and signaling pathways. It acts as a potent inhibitor, making it a valuable tool for investigating epidermal growth factor receptor (EGFR) and related tyrosine kinases. TSS offers CI-1033 for research purposes, adhering to strict quality control.
- IUPAC
- Canertinib dihydrochloride,N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride,N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride,PD183805
- Synonyms
- Canertinib dihydrochlorideN-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochlorideN-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloridePD183805CI-CY
Research in Cell Signaling
CI-1033 is utilised in scientific research to investigate signal transduction pathways, particularly those involving receptor tyrosine kinases like EGFR/ErbB-2. Its inhibitory properties allow for detailed studies of cellular responses to growth factor stimulation.
Development of Kinase Inhibitors
As a well-characterised kinase inhibitor, CI-1033 serves as a reference compound or research tool in the development of novel therapeutic agents targeting kinase activity in various biological contexts.
Cell Biology Studies
This compound is applied in cell biology experiments to probe the roles of specific kinases in cellular processes such as proliferation, differentiation, and survival. It aids in understanding the complex molecular mechanisms governing cell behaviour.
| Molecular weight | 558.86 |
|---|---|
| Empirical formula | C24H25ClFN5O3· 2HCl |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | DMSO: >10 mg/mLH2O: >10 mg/mL |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is CI-1033 used for?
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CI-1033 is used in scientific research, particularly for investigating cell signaling pathways, epidermal growth factor receptor (EGFR) activity, and kinase/phosphatase biology. It serves as a tool for studying cell proliferation and related cellular processes.
What is the CAS number and formula for CI-1033?
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The CAS number for CI-1033 is 289499-45-2. The empirical formula is C24H25ClFN5O3· 2HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies CI-1033 with an assay of ≥98% (HPLC). This product is supplied for research and development purposes and TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
How should CI-1033 be handled safely?
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CI-1033 is classified with GHS07 symbol and a 'Warning' signal word, carrying hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Users should avoid breathing dust/fume/gas/mist/vapours/spray and ensure good ventilation. In case of contact with eyes, rinse cautiously with water for several minutes and seek medical advice if irritation persists. Wear protective gloves and eye/face protection.
How is CI-1033 typically packed and exported?
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CI-1033 is supplied as a solid and typically stored at -20°C. It is carefully packed to maintain its integrity during domestic and international export, complying with all relevant shipping regulations for research chemicals.
How can I request a sample or quote for CI-1033?
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To request a sample or a quote for CI-1033, please visit the Tech Serve Solutions website and use the online inquiry form, or contact our sales department directly via email or phone.
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