Chlorodiisopropylphosphine

CAS 40244-90-4[(CH3)2CH]2PClCatalysis & Inorganic

Chlorodiisopropylphosphine (CAS: 40244-90-4), with the linear formula [(CH3)2CH]2PCl and a molecular weight of 152.60 g/mol, is a key organophosphorus compound. It serves as a valuable reagent and ligand precursor in organometallic chemistry and homogeneous catalysis, particularly for synthesizing phosphine ligands used in metal-catalyzed cross-coupling reactions like arylations.

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Chlorodiisopropylphosphine ([(CH3)2CH]2PCl) — chemical structure, CAS 40244-90-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisPhosphine CompoundsPhosphorus Precursors

01 /Applications

Ligand Synthesis

Chlorodiisopropylphosphine is a precursor for synthesising bulky, electron-rich phosphine ligands. These ligands are crucial in homogeneous catalysis, enhancing catalyst activity and selectivity in various organic transformations.

Organometallic Chemistry

This compound is employed in organometallic chemistry for the preparation of novel phosphorus-containing complexes. It allows for the controlled introduction of the diisopropylphosphino moiety into metal centres.

Catalysis

As a precursor to phosphine ligands, chlorodiisopropylphosphine indirectly facilitates catalytic processes. The resulting phosphine ligands are vital for reactions such as palladium-catalyzed arylations, Heck reactions, and Suzuki couplings.

02 /Properties

Molecular weight	152.60
Linear formula	[(CH3)2CH]2PCl
Assay	96%
Boiling point	69 °C/33 mmHg(lit.)
Density	0.959 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.475(lit.)

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H225Highly flammable liquid and vapour
H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat, sparks and open flames. No smoking
P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	4 °C / 39.2 °F
Transport (UN / ADR)	UN 2924 8(3) / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	F,C
Risk statements (R)	11-34
Safety statements (S)	16-26-27-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

40244-90-4

MDL number

MFCD00015027

PubChem substance

24860498

05 /Additional specifications

Ligand For	Arylations

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Chlorodiisopropylphosphine used for?

Chlorodiisopropylphosphine is primarily used as a precursor for synthesising phosphine ligands in organometallic chemistry and homogeneous catalysis, particularly for arylations and other cross-coupling reactions.

What are the CAS number and chemical formula for Chlorodiisopropylphosphine?

The CAS number is 40244-90-4, and the linear formula is [(CH3)2CH]2PCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Chlorodiisopropylphosphine with an assay of 96%. This product is not represented as USP, BP, or EP grade.

How should Chlorodiisopropylphosphine be handled?

Chlorodiisopropylphosphine is flammable and corrosive (H225-H314). Handling requires strict adherence to safety protocols, including the use of appropriate personal protective equipment such as gloves, goggles, face shields, and respiratory protection. Ensure adequate ventilation and keep away from ignition sources.

How is Chlorodiisopropylphosphine packed and shipped?

Chlorodiisopropylphosphine is classified as UN 2924, hazard class 8(3), packing group II. It is shipped according to regulations for flammable and corrosive substances. Consult with TSS for specific export and shipping details.

How can I request a quote or sample for Chlorodiisopropylphosphine?

To request a quote or sample, please contact the Tech Serve Solutions sales team via our website or direct contact details. Please specify the required quantity and your intended application.