Boc-N-Me-Leu-OH

CAS 53363-89-6(CH3)2CHCH2CH(COOH)N(CH3)COOC(CH3)3Chemical Synthesis

Boc-N-Me-Leu-OH (CAS 53363-89-6) is a N-methylated amino acid derivative, specifically Boc-protected N-methyl-L-leucine. With a molecular weight of 245.32 g/mol, it finds utility in chemical synthesis and peptide chemistry. This compound is particularly valuable in the creation of peptides containing unnatural amino acid residues, contributing to the development of novel biochemical tools and potential therapeutics.

IUPAC: Boc-N-methyl-L-leucine
Synonyms: Boc-N-methyl-L-leucine

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Boc-N-Me-Leu-OH ((CH3)2CHCH2CH(COOH)N(CH3)COOC(CH3)3) — chemical structure, CAS 53363-89-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisN-Methyl Amino AcidsPeptide Chemistry

01 /Applications

Peptide Synthesis

Used as a building block in solid-phase or solution-phase peptide synthesis to incorporate N-methyl-L-leucine residues. This modification can influence peptide conformation, stability, and biological activity.

Chemical Biology

Serves as a tool for researchers investigating the structure-activity relationships of peptides and proteins. Its incorporation can lead to modified peptides with altered binding properties or enzymatic resistance.

Medicinal Chemistry

Employed in the design and synthesis of novel drug candidates. The N-methylation and Boc-protection offer specific advantages in controlling pharmacokinetic properties and metabolic stability.

Organic Synthesis

Acts as a chiral intermediate in the synthesis of complex organic molecules. The defined stereochemistry of the leucine derivative is preserved during synthetic transformations.

02 /Properties

Molecular weight	245.32
Linear formula	(CH3)2CHCH2CH(COOH)N(CH3)COOC(CH3)3
Assay	≥99.0% (sum of enantiomers, TLC)
Optical activity	[α]20/D −36±2°, c = 1% in methylene chloride

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

53363-89-6

MDL number

MFCD00038522

Beilstein registry

2373250

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-N-Me-Leu-OH used for?

Boc-N-Me-Leu-OH is primarily used in peptide chemistry and chemical synthesis as a protected, N-methylated unnatural amino acid building block for creating modified peptides and complex organic molecules.

What is the CAS number and formula for Boc-N-Me-Leu-OH?

The CAS number for Boc-N-Me-Leu-OH is 53363-89-6. Its linear formula is (CH3)2CHCH2CH(COOH)N(CH3)COOC(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-N-Me-Leu-OH with an assay of ≥99.0% (sum of enantiomers, TLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.

How should Boc-N-Me-Leu-OH be handled safely?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany 3, indicating a high hazard to water.

How is Boc-N-Me-Leu-OH shipped and exported?

Boc-N-Me-Leu-OH is expertly packed and shipped globally by Tech Serve Solutions, adhering to all necessary regulations for the export of fine chemicals.