Bis(4-methylphenyl)chlorophosphine
Bis(4-methylphenyl)chlorophosphine (CAS 1019-71-2) is an air- and moisture-sensitive organophosphorus reagent with the molecular formula C14H14ClP and a molar mass of 248.69 g/mol. Also known as chlorodi-p-tolylphosphine, this colourless to pale liquid serves chiefly as a phosphine precursor in synthetic and organometallic chemistry, where its reactive P-Cl bond is used to install di(p-tolyl)phosphino groups and build ligands for palladium- and nickel-catalysed transformations.
- IUPAC
- P,P-Bis(4-methylphenyl)-phosphinous chloride,Chlorodi-p-tolylphosphine
- Synonyms
- Bis(4-methylphenyl)chlorophosphineChlorodi-p-tolylphosphineP,P-Bis(4-methylphenyl)phosphinous chlorideDi-p-tolylchlorophosphineChlorobis(4-methylphenyl)phosphineBis(4-methylphenyl)phosphinous chloride
Palladium cross-coupling catalysts
Used as a reactant in the synthesis of palladium catalysts and phosphine ligands for carbon-carbon bond-forming cross-coupling reactions, where the di(p-tolyl)phosphino moiety tunes the steric and electronic environment at the metal.
Nickel ligand and complex synthesis
Serves as a building block for ligands used in nickel(0)-catalysed isomerisation reactions and for phosphinosulfonamide nickel complexes employed in oligomerisation chemistry.
Phosphinylation reagent
The reactive phosphorus-chlorine bond makes it a convenient reagent for phosphinylation, allowing introduction of the di-p-tolylphosphine group onto alcohols, amines and other nucleophiles.
Asymmetric and metathesis catalysis
Applied as a reactant in palladium-catalysed intramolecular asymmetric allylic amination and ring-closing metathesis sequences, supporting ligand design for stereoselective synthesis.
Phosphorus precursor for research synthesis
Functions broadly as a phosphorus precursor and phosphine compound in chemical synthesis programmes, enabling preparation of tertiary phosphines, phosphine oxides and related organophosphorus derivatives.
| Molecular weight | 248.69 |
|---|---|
| Empirical formula | C14H14ClP |
| Assay | 96% |
| Density | 1.1 g/mL at 25 °C |
| Refractive index | n20/D 1.501 |
| Application | Reactant for synthesis of:• Palladium catalysts for C-C bond forming cross-coupling reactions1• Ligands for nickel(0)-catalyzed isomerization reactions2• Phosphinosulfonamide nickel complexes for oligomerization reactions3Reactant for:• Pd-catalyzed intramolecular asymmetric allylic amination and ring-closing metathesis4• Phosphinylation reactions5 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(4-methylphenyl)chlorophosphine used for?
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It is used mainly as an organophosphorus reagent and phosphine precursor. Its reactive P-Cl bond installs the di(p-tolyl)phosphino group, supporting the synthesis of palladium cross-coupling catalysts, nickel ligands and complexes, phosphinylation reactions, and ligands for asymmetric allylic amination and ring-closing metathesis.
What is the CAS number and molecular formula of Bis(4-methylphenyl)chlorophosphine?
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The CAS number is 1019-71-2 and the molecular formula is C14H14ClP (Hill notation), with a molecular weight of 248.69 g/mol. It is also known as chlorodi-p-tolylphosphine and P,P-bis(4-methylphenyl)phosphinous chloride.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this material at a typical assay of 96%, as a research and synthesis-grade reagent (reported density 1.1 g/mL at 25 °C, refractive index n20/D 1.501). We do not represent it as USP, BP or EP pharmacopoeia grade. Specific lot data can be confirmed on request.
What are the safety hazards and how should it be handled?
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It carries GHS05 with the signal word Danger and hazard statement H314 (causes severe skin burns and eye damage), and it reacts violently with water. Handle it under dry, inert conditions away from moisture, using gloves, goggles, face protection and a suitable respirator (ABEK / multi-purpose cartridge). Always consult the Safety Data Sheet before use.
Is Bis(4-methylphenyl)chlorophosphine a hazardous or dangerous good for transport?
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Yes. It is classified for transport as UN 3265, Class 8 (corrosive), Packing Group III, and has a German Water Hazard Class of WGK 3 (severely hazardous to water). It must be shipped as a corrosive dangerous good with compliant packaging and documentation.
How is Bis(4-methylphenyl)chlorophosphine packed, shipped and exported?
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Because it is moisture-sensitive and corrosive, it is packed in tightly sealed, inert, moisture-excluding containers sized to the order and shipped as UN 3265 Class 8 dangerous goods with full hazard labelling and documentation. Tech Serve Solutions exports worldwide in line with applicable transport and customs requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and export details. Please reference Bis(4-methylphenyl)chlorophosphine, CAS 1019-71-2, when enquiring.
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