Bis(2,4,6-trimethylphenyl)phosphorus chloride
Bis(2,4,6-trimethylphenyl)phosphorus chloride (CAS 67950-05-4), commonly known as chlorodimesitylphosphine, is an organophosphorus chlorophosphine of formula C18H22ClP with a molecular weight of 304.79. Bearing two bulky, electron-rich mesityl groups on a reactive P-Cl bond, it is a moisture-sensitive synthetic reagent and ligand precursor used in catalysis, cross-coupling and organometallic chemistry. Tech Serve Solutions supplies it as a research-grade reagent, typically at 95% assay, to laboratories and manufacturers worldwide.
- IUPAC
- Chlorodimesitylphosphine
- Synonyms
- Bis(2,4,6-trimethylphenyl)phosphorus chlorideChlorodimesitylphosphineChlorobis(2,4,6-trimethylphenyl)phosphineDimesitylphosphinous chlorideDimesitylchlorophosphineCAS 67950-05-4
Phosphine ligand synthesis
Used as a precursor to dimesitylphosphine and related sterically hindered tertiary phosphines. The reactive phosphorus-chlorine bond is readily displaced by organometallic or hydride reagents to install the bulky dimesitylphosphino group.
Catalysis and cross-coupling
Serves as a building block for electron-rich, bulky phosphine ligands of the type employed in transition-metal catalysis and cross-coupling reactions. Such ligands are valued for stabilising active metal centres in organic synthesis.
Organometallic and coordination chemistry
Functions as a phosphorus precursor for the preparation of metal-phosphine complexes. The dimesityl substitution provides significant steric bulk that can influence the geometry and reactivity of the resulting complexes.
Research and chemical synthesis reagent
Applied in academic and industrial research as a versatile P-Cl reagent for constructing phosphorus-carbon bonds and for further functionalisation of the phosphorus centre.
| Molecular weight | 304.79 |
|---|---|
| Empirical formula | C18H22ClP |
| Assay | 95% |
| Melting point | 80-85 °C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(2,4,6-trimethylphenyl)phosphorus chloride used for?
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It is used primarily as a reagent and ligand precursor in catalysis and organometallic chemistry. The reactive P-Cl bond allows it to be converted into bulky, electron-rich dimesitylphosphine ligands used in transition-metal catalysis and cross-coupling, and to build phosphorus-carbon bonds in chemical synthesis.
What is the CAS number and molecular formula of Bis(2,4,6-trimethylphenyl)phosphorus chloride?
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The CAS number is 67950-05-4 and the molecular formula is C18H22ClP, with a molecular weight of 304.79. It is also known as chlorodimesitylphosphine.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this material as a research/technical-grade reagent, typically at an assay of 95%. We do not represent it as a USP, BP or EP pharmacopoeial grade. Current specifications and a certificate of analysis are provided on request for each lot.
Is Bis(2,4,6-trimethylphenyl)phosphorus chloride hazardous, and how should it be handled?
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Yes. It is classified GHS05 with the signal word Danger and hazard statement H314 (causes severe skin burns and eye damage). It is corrosive and moisture-sensitive. Handle under dry, inert conditions with eye and face protection, suitable gloves and an N100/P3-type respirator (precautionary statements P280, P305+P351+P338, P310), and follow the Safety Data Sheet.
How is Bis(2,4,6-trimethylphenyl)phosphorus chloride packed, shipped and exported?
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It is packed in appropriate sealed, moisture-resistant containers sized to order and shipped as a Class 8 corrosive dangerous good under UN 3261, packing group II. Tech Serve Solutions exports worldwide with full transport documentation and the relevant Safety Data Sheet.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and we will provide a quotation, current specification and lead time. Samples can be arranged subject to availability and applicable dangerous-goods shipping requirements.
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