Biphenyl-4-sulfonyl chloride
Biphenyl-4-sulfonyl chloride (CAS: 1623-93-4) is an organic compound with the formula C6H5C6H4SO2Cl and a molecular weight of 252.72 g/mol. It serves as a key intermediate and reactant in various organic syntheses. This sulfonyl halide is particularly valuable for the preparation of complex organic molecules, including potential therapeutic agents and compounds for chemical research, highlighting its role in advanced chemical synthesis.
- IUPAC
- (4-Biphenylyl)sulfonyl chloride,4-(Chlorosulfonyl)biphenyl,4-Phenylbenzenesulfonic acid chloride,4-Phenylbenzenesulfonyl chloride,p-Phenylbenzenesulfonyl chloride,p-Biphenylsulfonyl chloride
- Synonyms
- (4-Biphenylyl)sulfonyl chloride4-(Chlorosulfonyl)biphenyl4-Phenylbenzenesulfonic acid chloride4-Phenylbenzenesulfonyl chloridep-Phenylbenzenesulfonyl chloridep-Biphenylsulfonyl chloride
Anticancer Agent Precursors
Biphenyl-4-sulfonyl chloride is employed as a reactant in the preparation of anilinopyrimidinesulfonamides, which are investigated for their potential anticancer properties.
Hypoxia-Inducible Factor Pathway Inhibitors
This compound is utilised in the synthesis of molecules designed to inhibit the hypoxia-inducible factor pathway, a target in various disease research areas.
HDAC Inhibitors Synthesis
It serves as a precursor in the preparation of hydroxy-sulfonyl-piperidinyl butyramides, which are explored as HDAC inhibitors with potential applications in antitumor therapies.
C-Arylation Reactions
Biphenyl-4-sulfonyl chloride is a substrate in palladium-catalyzed desulfitative C-arylation reactions, a method for forming carbon-carbon bonds.
| Molecular weight | 252.72 |
|---|---|
| Linear formula | C6H5C6H4SO2Cl |
| Application | Reactant for:• Preparation of anilinopyrimidinesulfonamides as potential anticancer agents1• Synthesis of inhibitors of the hypoxia inducible factor pathway2• Preparation of hydroxy-sulfonyl-piperidinyl butyramides as HDAC inhibitors and potential antitumors3• Palladium-catalyzed desulfitative C-arylation4 |
| Melting point | 103-108 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Biphenyl-4-sulfonyl chloride used for?
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Biphenyl-4-sulfonyl chloride is used as a reactant in organic synthesis, notably for preparing potential anticancer agents, inhibitors of the hypoxia-inducible factor pathway, and HDAC inhibitors. It also participates in palladium-catalyzed desulfitative C-arylation.
What are the CAS number and chemical formula for Biphenyl-4-sulfonyl chloride?
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The CAS number is 1623-93-4, and the chemical formula is C6H5C6H4SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Biphenyl-4-sulfonyl chloride suitable for research and chemical synthesis. The specific assay and purity details are available upon request or on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for Biphenyl-4-sulfonyl chloride?
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Biphenyl-4-sulfonyl chloride is a corrosive substance (GHS05, Danger) that causes severe skin burns and eye damage (H314). It reacts violently with water. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (N100 or P3), is essential. Handle in a well-ventilated area.
Is Biphenyl-4-sulfonyl chloride shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter and can ship Biphenyl-4-sulfonyl chloride internationally, adhering to all relevant shipping regulations for hazardous materials (UN 3261, Class 8, PGII).
How can I request a quote or sample for Biphenyl-4-sulfonyl chloride?
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To request a quote or a sample of Biphenyl-4-sulfonyl chloride, please contact our sales department through the website or by phone, providing your specific requirements.
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