BIO
6-Bromoindirubin-3′-oxime (CAS: 667463-62-9, C16H10BrN3O2, MW: 356.17) is a dark red powder supplied by TSS. This bioactive small molecule is a potent inhibitor of Glycogen Synthase Kinase 3 (GSK3) and other related kinases. It is frequently employed in biochemical research, particularly in studies related to cell signaling, cell biology, and molecular biology, serving as a valuable tool for investigating kinase-dependent pathways.
- IUPAC
- (2’Z,3’E)-6-Bromoindirubin-3′-oxime,6-BIO,6BIO
- Synonyms
- (2’Z,3’E)-6-Bromoindirubin-3′-oxime6-BIO6BIO
Kinase Inhibition Research
This compound acts as a specific inhibitor for Glycogen Synthase Kinase 3 (GSK3), making it a crucial tool for researchers studying cellular signaling pathways and the role of kinases in various biological processes. Its applications extend to exploring treatments for diseases associated with aberrant kinase activity.
Cell Biology Studies
As a bioactive small molecule, 6-Bromoindirubin-3′-oxime is utilized in cell-based assays to investigate the effects of GSK3 inhibition on cellular functions, differentiation, and survival. It aids in understanding complex cellular mechanisms and post-translational modifications.
Neuroscience Research
Due to GSK3's involvement in neuronal function and diseases like Alzheimer's, this inhibitor is employed in neuroscience research to explore therapeutic strategies targeting neurodegenerative conditions and other neurological disorders.
Biochemical Tool
It serves as a valuable reagent for proteomics and molecular biology laboratories, enabling the study of protein kinase inhibitors and their downstream effects in various biochemical pathways.
| Molecular weight | 356.17 |
|---|---|
| Empirical formula | C16H10BrN3O2 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | dark red |
| Solubility | DMSO: >5 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | wet ice |
|---|---|
| Storage Condition | protect from light |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Bromoindirubin-3′-oxime used for?
+
6-Bromoindirubin-3′-oxime is primarily used as a research tool for studying Glycogen Synthase Kinase 3 (GSK3) inhibition, cell signaling, cell biology, neuroscience, and molecular biology. It is a bioactive small molecule employed in biochemical research.
What is the CAS number and formula for 6-Bromoindirubin-3′-oxime?
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The CAS number for 6-Bromoindirubin-3′-oxime is 667463-62-9, and its empirical formula is C16H10BrN3O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Bromoindirubin-3′-oxime with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for this product?
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This product is classified with GHS07 symbol and 'Warning' signal word, with hazard statements H315, H319, and H335. Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive handling instructions.
How is 6-Bromoindirubin-3′-oxime shipped and stored?
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6-Bromoindirubin-3′-oxime is shipped on wet ice and should be stored at 2-8°C, protected from light, to maintain its stability and efficacy.
How can I request a quote or sample?
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To request a quote or sample of 6-Bromoindirubin-3′-oxime, please contact our sales team through the website or by phone, providing your specific requirements.
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