Bexarotene
Bexarotene (CAS: 153559-49-0, C24H28O2, MW: 348.48) is a synthetic retinoid analogue. This white to beige powder functions as a selective agonist for retinoid X receptors (RXRs), playing a crucial role in gene regulation. Its applications are primarily within research settings, focusing on cell biology, signalling pathways, and gene expression studies.
- IUPAC
- 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid,LGD-1069,SR-11247
Retinoid Receptor Modulation
Bexarotene acts as a potent agonist for all three retinoid X receptor (RXR) subtypes (alpha, beta, and gamma). This makes it a valuable tool for studying the complex roles of RXRs in cellular differentiation, proliferation, and apoptosis.
Gene Expression Studies
As a modulator of RXRs, Bexarotene influences the transcription of various genes. Researchers utilise it to investigate gene regulation pathways involved in diverse biological processes and disease states.
Cell Biology Research
This compound is employed in cell biology laboratories to explore the effects of retinoid signalling on cellular behaviour and function. It aids in understanding mechanisms of cell growth and development.
Neuroscience and Signalling Pathways
Bexarotene serves as a probe in neuroscience research to investigate the involvement of RXRs in neuronal function and signalling cascades. Its use can help elucidate pathways related to neuroprotection and neurodegenerative diseases.
| Molecular weight | 348.48 |
|---|---|
| Empirical formula | C24H28O2 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | DMSO: ≥15 mg/mL (warmed) |
| Storage temperature | −20°C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bexarotene used for?
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Bexarotene is primarily used in research settings for studies in cell biology, cell signaling, neuroscience, gene regulation, and as a PPAR and RXR regulator. It functions as a selective agonist for retinoid X receptors.
What are the CAS number and formula for Bexarotene?
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The CAS number for Bexarotene is 153559-49-0, and its empirical formula is C24H28O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bexarotene with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Bexarotene be handled and stored?
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Bexarotene is classified under WGK Germany 3, indicating it is hazardous. It should be handled with appropriate personal protective equipment in a well-ventilated area. Store at -20°C.
How is Bexarotene packed, shipped, and exported?
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Bexarotene is supplied as a powder and exported by TSS in compliance with all relevant international shipping regulations for chemical substances.
How can I request a sample or quote for Bexarotene?
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To request a sample or quote for Bexarotene, please contact the TSS sales team through our website or by direct enquiry.
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