Astemizole
Astemizole (CAS 68844-77-9), with the molecular formula C28H31FN4O and a molecular weight of 458.57 g/mol, is a benzimidazole derivative. It is recognised for its role as a selective histamine H1 receptor antagonist and also exhibits activity related to drug metabolism, particularly as a substrate and inhibitor of CYP3A4. This compound is valuable in biochemical research and as a building block in chemical synthesis.
- IUPAC
- 1-(4-Fluorobenzyl)-2-(1-[4-methoxyphenethyl]piperidin-4-yl)aminobenzimidazole
Histamine H1 Receptor Antagonist Research
Astemizole is utilised in research settings to study histamine H1 receptor function and signalling pathways. Its selective antagonistic properties make it a useful tool for investigating allergic responses and related physiological processes.
Drug Metabolism Studies
This compound serves as a research chemical to explore drug and xenobiotic metabolism, specifically its interactions with cytochrome P450 enzymes such as CYP3A4. It is used to understand enzyme inhibition and substrate relationships in metabolic pathways.
Chemical Synthesis and Building Block
As a heterocyclic building block, Astemizole is employed in the synthesis of novel chemical entities. Its structure provides a versatile scaffold for medicinal chemistry programmes and the development of new compounds.
Cell Biology and Signaling Research
Researchers use Astemizole in cell-based assays to investigate cellular responses and signalling cascades, particularly those influenced by histamine receptors and drug metabolising enzymes.
| Molecular weight | 458.57 |
|---|---|
| Empirical formula | C28H31FN4O |
| Assay | ≥99% |
| Solubility | DMSO: >20 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | desiccatedprotect from light |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Astemizole used for?
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Astemizole is used in research for studying histamine H1 receptor antagonism, drug metabolism (particularly CYP3A4 interactions), and as a building block in chemical synthesis. It is also utilised in cell biology and neuroscience research.
What are the CAS number and molecular formula for Astemizole?
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The CAS number for Astemizole is 68844-77-9, and its molecular formula is C28H31FN4O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Astemizole with a purity of ≥99%. It is supplied for research and laboratory use and is not intended for human or animal consumption, nor as a USP, BP, EP, or pharmaceutical-grade substance unless explicitly stated otherwise.
What are the safety considerations when handling Astemizole?
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Astemizole is labelled with GHS07 (Warning) and carries hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be worn. Handle in a well-ventilated area. Consult the Safety Data Sheet (SDS) for full details.
How is Astemizole packed, shipped, and exported?
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Astemizole is typically packed to ensure stability during transit and is exported globally by Tech Serve Solutions in compliance with all relevant regulations. Storage is recommended at 2-8°C, desiccated, and protected from light.
How can I request a sample or quote for Astemizole?
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To request a sample or a quote for Astemizole, please contact the Tech Serve Solutions sales team through our website or by direct inquiry, providing your specific requirements.
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