Aristolochic acid I
Aristolochic acid I (CAS 313-67-7), with the chemical formula C17H11NO7 and a molecular weight of 341.27 g/mol, is a natural product known for its potent biological activities. It functions as a phospholipase A2 inhibitor. Research indicates Aristolochic acid I induces tumor formation in animal models and apoptosis in human renal cells, highlighting its significance in cancer research and toxicology studies.
- IUPAC
- TR 1736
Phospholipase A2 Inhibition
Aristolochic acid I is recognised as a potent inhibitor of phospholipase A2 (PLA2). This activity makes it a valuable tool for researchers investigating the role of PLA2 enzymes in various biological processes and disease states.
Cancer Research
The compound's ability to induce tumor formation in preclinical models and apoptosis in renal cells positions it as a subject of interest in cancer research. It serves as a chemical probe for studying carcinogenesis and renal toxicity mechanisms.
Biochemical Studies
As a bioactive small molecule, Aristolochic acid I is used in biochemical and cell biology research to explore cellular pathways, particularly those involving lipid signaling and cell death.
| Molecular weight | 341.27 |
|---|---|
| Empirical formula | C17H11NO7 |
| Form | powder |
| Colour | yellow |
| Solubility | DMSO: solubleethanol: soluble |
| Storage temperature | 2-8°C |
| Application | Aristolochic acid I is a potent phospholipase A2 inhibitor. Aristolochic acid I induces tumor formation in rat kidneys and apoptosis in human renal proximal tubular epithelial cells. |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1544 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 7-35-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Aristolochic acid I used for?
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Aristolochic acid I is primarily used as a research chemical. It is known to be a potent phospholipase A2 inhibitor and is studied for its role in inducing tumor formation and apoptosis in renal cells, making it relevant for cancer research and toxicology studies.
What is the CAS number and chemical formula for Aristolochic acid I?
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The CAS number for Aristolochic acid I is 313-67-7, and its chemical formula is C17H11NO7.
What grade and purity does Tech Serve Solutions supply for Aristolochic acid I?
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Tech Serve Solutions supplies Aristolochic acid I as a yellow powder. The specific purity is not detailed in the provided data, and TSS does not represent this product as USP, BP, or EP grade.
How should Aristolochic acid I be handled safely?
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Aristolochic acid I is classified as acutely toxic (H301). Handling requires strict adherence to safety protocols, including wearing eyeshields, face shields, gloves, and appropriate respiratory protection (type P2 respirator cartridges). Store at 2-8°C.
Is Aristolochic acid I a controlled substance?
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The provided data does not indicate that Aristolochic acid I is a controlled substance.
How is Aristolochic acid I shipped and exported?
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Aristolochic acid I is classified under UN 1544, Hazard Class 6.1 (Toxic substances), Packing Group III. Tech Serve Solutions is a global supplier and exporter of fine chemicals, capable of handling international shipments in compliance with regulations.
How can I request a quote or sample for Aristolochic acid I?
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To request a quote or sample for Aristolochic acid I, please contact Tech Serve Solutions directly through our established channels for personalised service and to discuss your specific requirements.
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