Antipain dihydrochloride from microbial source
Antipain dihydrochloride (CAS 37682-72-7), with the molecular formula C27H44N10O6 · 2 HCl, is a potent protease inhibitor isolated from microbial sources. This compound is a valuable research tool, primarily employed in biochemical studies to investigate the roles of various proteases, including serine proteases, cysteine proteases, and metalloproteinases. Its ability to inhibit key enzymes makes it instrumental in understanding cellular processes such as apoptosis and protein degradation.
- IUPAC
- N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe
Protease Inhibition Studies
Antipain dihydrochloride is widely used to selectively inhibit a range of proteases, including papain, trypsin, cathepsins, and calpain I. This makes it crucial for researchers studying enzymatic mechanisms and pathways.
Apoptosis Research
By inhibiting proteases involved in programmed cell death, Antipain dihydrochloride aids in the investigation of apoptotic pathways. It helps researchers elucidate the role of specific proteases in initiating or regulating apoptosis.
Biochemical Assays
The compound serves as a standard inhibitor in biochemical assays designed to characterise enzyme activity and specificity. Its known inhibition profiles are essential for validating experimental results.
| Molecular weight | 677.62 |
|---|---|
| Empirical formula | C27H44N10O6 · 2 HCl |
| Solubility | H2O: soluble50 mg/mL1-butanol: soluble1-propanol: solubleDMSO: solubleethanol: solublemethanol: soluble |
| Storage temperature | −20°C |
| Application | Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Antipain dihydrochloride used for?
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Antipain dihydrochloride is used as a research chemical to inhibit various proteases, aiding in the study of cellular processes like apoptosis and protein degradation. It is a potent inhibitor of enzymes such as papain, trypsin, cathepsins, and calpains.
What are the CAS number and formula for Antipain dihydrochloride?
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The CAS number for Antipain dihydrochloride is 37682-72-7 and its molecular formula is C27H44N10O6 · 2 HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Antipain dihydrochloride at a PREMIUM quality level. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated in the product specifications.
What are the safety precautions for handling Antipain dihydrochloride?
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When handling Antipain dihydrochloride, it is essential to use appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The WGK Germany classification is 3, indicating a high hazard to water.
How is Antipain dihydrochloride packed, shipped, and exported?
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Antipain dihydrochloride is stored at -20°C. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, ensuring proper packaging and adherence to international shipping regulations.
How can I request a sample or quote for Antipain dihydrochloride?
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To request a sample or a quote for Antipain dihydrochloride, please contact our sales team through the website or by phone. We are available to assist with your research and procurement needs.
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