Amifostine trihydrate
Amifostine trihydrate (CAS 112901-68-5) is a white powder with the empirical formula C5H15N2O3PS · 3 H2O and a molecular weight of 268.27 g/mol. As a potent antioxidant and cytoprotectant, amifostine finds application in mitigating radiation damage, particularly in renal protection during certain cancer therapies. It also exhibits activity in counteracting degenerative effects of radiation on tissues.
- IUPAC
- 2-(3-Aminopropyl)aminoethyl phosphorothioate,WR2721
- Synonyms
- 2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721
Radioprotection in Cancer Therapy
Amifostine trihydrate may be used to provide renal protection during peptide receptor radionuclide therapy (PRRT) involving somatostatin analogs. It helps reduce kidney radiation dose and mitigate radiation-induced damage.
Mitigation of Radiation-Induced Degeneration
Research indicates that amifostine can remediate the degenerative effects of radiation on the mineralization capacity of murine mandibles, suggesting a role in tissue protection.
Antioxidant and Cytoprotective Research
As a bio-active small molecule, amifostine trihydrate is employed in cell biology and cancer research for its antioxidant and cytoprotective properties, particularly concerning cell stress and nitric oxide pathways.
| Molecular weight | 268.27 |
|---|---|
| Empirical formula | C5H15N2O3PS · 3 H2O |
| Assay | ≥97% (TLC) |
| Form | powder |
| Storage temperature | 2-8°C |
| Application | Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible. |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Amifostine trihydrate used for?
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Amifostine trihydrate is used for its antioxidant and cytoprotective properties, including potential renal protection during cancer therapies and mitigating radiation-induced tissue damage. It is also utilized in cell biology and cancer research.
What is the CAS number and formula for Amifostine trihydrate?
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The CAS number for Amifostine trihydrate is 112901-68-5, and its empirical formula is C5H15N2O3PS · 3 H2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Amifostine trihydrate with a purity of ≥97% (TLC). This product is supplied for research and laboratory use and is not represented as USP, BP, or EP grade.
What are the safety considerations when handling Amifostine trihydrate?
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Amifostine trihydrate is classified as harmful if swallowed (H302). When handling, use a dust mask type N95, eyeshields, and gloves. Ensure adequate ventilation and avoid dust formation. Refer to the Safety Data Sheet for comprehensive information.
How is Amifostine trihydrate shipped and exported?
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Amifostine trihydrate is typically stored at 2-8°C. Tech Serve Solutions, as a specialist global supplier, can export this chemical according to international shipping regulations. Please contact us for specific export requirements.
How can I request a sample or quote for Amifostine trihydrate?
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To request a sample or a quote for Amifostine trihydrate, please use the contact form on our website or call our sales department. Provide your contact details and the quantity required.
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