8-Hydroxy-2′-deoxyguanosine
8-Hydroxy-2′-deoxyguanosine (CAS 88847-89-6), with the molecular formula C10H13N5O5 and a molecular weight of 283.24 g/mol, is a DNA oxidation product. It is primarily utilised in research settings to investigate oxidative stress, DNA damage, and repair mechanisms within cellular biology and related fields. This compound serves as a valuable biomarker for oxidative damage and is employed in studies of ageing and disease.
- IUPAC
- 8-Oxo-7,8-dihydro-2′-deoxyguanosine,8-Oxo-dG
- Synonyms
- 8-Oxo-dG8-Oxo-7,8-dihydro-2′-deoxyguanosine
Biomarker for Oxidative DNA Damage
8-Hydroxy-2′-deoxyguanosine is widely recognised as a critical biomarker for oxidative stress-induced DNA damage. Its presence and levels in biological samples are indicative of the extent of oxidative insult to genetic material.
Cell Biology Research
This compound is essential for studies in cell biology, particularly those focusing on cellular responses to oxidative stress. It aids in understanding DNA repair pathways and the mechanisms cells employ to mitigate damage.
Neuroscience and Aging Studies
In neuroscience, 8-Hydroxy-2′-deoxyguanosine is used to investigate the role of oxidative damage in neurodegenerative processes and ageing. Elevated levels are often observed in conditions associated with neuronal damage.
Nitric Oxide Research
The compound is relevant in research concerning nitric oxide signalling and its downstream effects, particularly how NO contributes to oxidative stress and subsequent DNA modifications.
| Molecular weight | 283.24 |
|---|---|
| Empirical formula | C10H13N5O5 |
| Assay | ≥98% (TLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 8-Hydroxy-2′-deoxyguanosine used for?
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8-Hydroxy-2′-deoxyguanosine is used as a biomarker for oxidative DNA damage, in cell biology research, cell signalling, neuroscience, and studies on cell stress, nitric oxide, and oxidative stress proteins.
What are the CAS number and formula for 8-Hydroxy-2′-deoxyguanosine?
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The CAS number for 8-Hydroxy-2′-deoxyguanosine is 88847-89-6, and its empirical formula is C10H13N5O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 8-Hydroxy-2′-deoxyguanosine with an assay of ≥98% (TLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for 8-Hydroxy-2′-deoxyguanosine?
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When handling 8-Hydroxy-2′-deoxyguanosine, it is essential to wear eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The product has a WGK Germany classification of 3.
How is 8-Hydroxy-2′-deoxyguanosine shipped and exported?
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8-Hydroxy-2′-deoxyguanosine is typically stored at 2-8°C and can be shipped and exported globally by Tech Serve Solutions. Please contact us for specific shipping details.
How can I request a sample or quote for 8-Hydroxy-2′-deoxyguanosine?
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To request a sample or quote for 8-Hydroxy-2′-deoxyguanosine, please visit the product page on the Tech Serve Solutions website or contact our sales team directly.
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