7-Nitroindole
7-Nitroindole (CAS 6960-42-5), with the molecular formula C8H6N2O2 and a molecular weight of 162.15 g/mol, is a key heterocyclic building block. This compound is widely employed as a reactant in the synthesis of various biologically active molecules. Its applications span the development of potential pharmaceuticals, including protein kinase inhibitors, fructose 1,6-bisphosphatase inhibitors, and anticoagulants like Factor Xa inhibitors.
- IUPAC
- NSC 69874
Synthesis of Protein Kinase Inhibitors
7-Nitroindole serves as a crucial intermediate in the preparation of various protein kinase inhibitors. These compounds are of significant interest in medicinal chemistry for their potential therapeutic applications.
Development of Enzyme Inhibitors
The compound is utilised in the synthesis of potential inhibitors for enzymes such as fructose 1,6-bisphosphatase and Inosine Monophosphate Dehydrogenase (IMPDH). Such inhibitors are investigated for various metabolic and therapeutic targets.
Anticoagulant Research
7-Nitroindole is employed as a reactant in the synthesis of Factor Xa inhibitors. These molecules are important targets for developing novel anticoagulant therapies.
Mineralocorticoid Receptor Antagonists
This chemical is a precursor in the development of antagonists for the mineralocorticoid receptor. These agents are explored for conditions influenced by this receptor pathway.
Antitumor Agent Synthesis
It is used in the preparation of antitumor sulfonamides, contributing to the synthesis of potential cancer therapeutic agents.
| Molecular weight | 162.15 |
|---|---|
| Empirical formula | C8H6N2O2 |
| Assay | 97% |
| Application | Reactant for preparation of:• Protein kinase inhibitors1• Potential fructose 1,6-bisphosphatase inhibitors2• Factor Xa inhibitors3• Antagonist of the mineralocorticoid receptor4• Antitumor sulfonamides5• Inosine monophosphate dehydrogenase (IMPDH) inhibitors6• Subtype-selective cyclooxygenase (COX) inhibitors7• Thrombin protease-activated receptor (PAR-1) ligands8 |
| Melting point | 94-98 °C(lit.) |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 68 |
| Safety statements (S) | 36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 7-Nitroindole primarily used for?
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7-Nitroindole is primarily used as a reactant and building block in chemical synthesis, particularly for preparing potential pharmaceuticals such as protein kinase inhibitors, enzyme inhibitors, and anticoagulant agents.
What is the CAS number and formula for 7-Nitroindole?
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The CAS number for 7-Nitroindole is 6960-42-5, and its molecular formula is C8H6N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 7-Nitroindole with an assay of 97%. This is a research or technical grade material and is not represented as USP, BP, or EP.
What are the safety considerations when handling 7-Nitroindole?
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When handling 7-Nitroindole, it is essential to wear appropriate personal protective equipment, including eyeshields and gloves. It is classified as harmful (Xn) with risk statement R68 (possible risk of irreversible effects). Always follow appropriate laboratory safety protocols.
How is 7-Nitroindole packed, shipped, and exported?
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7-Nitroindole is carefully packed to ensure product integrity during transit. As a global supplier, Tech Serve Solutions exports chemicals worldwide, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote for 7-Nitroindole?
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To request a sample or obtain a quotation for 7-Nitroindole, please contact the Tech Serve Solutions sales team through our website or by phone, providing your contact details and quantity requirements.
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