7-Fluoro-4-hydroxycoumarin
7-Fluoro-4-hydroxycoumarin (CAS: 2145-27-9; C9H5FO3; MW: 180.13) is a fluorinated heterocyclic compound supplied by Tech Serve Solutions for chemical synthesis. It serves as a key reactant in advanced organic synthesis, enabling the creation of complex molecules. Its applications include the enantioselective synthesis of polycyclic coumarins and the preparation of potential anti-cancer agents, highlighting its utility in pharmaceutical research and fine chemical development.
- IUPAC
- 7-Fluoro-4-hydroxy-1(2H)-benzopyran-2-one,7-Fluoro-4-hydroxy-2H-chromen-2-one
Synthesis of Polycyclic Coumarins
Used as a reactant in the enantioselective synthesis of polycyclic coumarins via amine-imine-catalyzed asymmetric Michael addition reactions with cyclic enones. This process allows for the controlled formation of complex coumarin structures.
Preparation of NQO1 Inhibitors
Serves in the preparation of dicoumarol analogs designed to inhibit human NAD(P)H quinone oxidoreductase-1 (NQO1). These analogs have shown activity against pancreatic and colon cancer cells.
Asymmetric Synthesis of Warfarin Anticoagulants
Facilitates the one-step, atom-economic asymmetric synthesis of optically active warfarin anticoagulants through imidazolidinecarboxylic acid-catalyzed Michael addition with unsaturated ketones.
Synthesis of Functionalized α-Keto Esters
Acts as a substrate in the asymmetric synthesis of functionalized α-keto esters and their derivatives. This is achieved via direct Michael addition with unsaturated α-keto esters catalyzed by bisoxazoline-copper(II) complexes.
| Molecular weight | 180.13 |
|---|---|
| Empirical formula | C9H5FO3 |
| Application | Reactant for:• Enantioselective synthesis of polycyclic coumarins via in situ formed primary amine-imine-catalyzed asymmetric Michael addition to cyclic enones1• Preparation of dicoumarol analogs as inhibitors of human NAD(P)H quinone oxidoreductase-1 (NQO1) as agents active against human pancreatic and colon cancer cells2• Imidazolidinecarboxylic acid-catalyzed asymmetric Michael reaction with unsaturated ketones in a highly atom-economic catalytic one-step formation of optically active warfarin anticoagulant3• Asymmetric synthesis of functionalized α-keto esters and their hemiketal and hemiaminal derivatives via direct Michael addition with unsaturated α-keto esters catalyzed by bisoxazoline-copper(II) complexes4 |
| Melting point | 220-225 °C |
Hazard statements
- H302Harmful if swallowed
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 7-Fluoro-4-hydroxycoumarin used for?
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7-Fluoro-4-hydroxycoumarin is used as a reactant in various asymmetric synthesis applications, including the preparation of polycyclic coumarins, dicoumarol analogs with potential anti-cancer activity, and optically active warfarin anticoagulants.
What are the CAS number and formula for 7-Fluoro-4-hydroxycoumarin?
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The CAS number for 7-Fluoro-4-hydroxycoumarin is 2145-27-9, and its empirical formula is C9H5FO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 7-Fluoro-4-hydroxycoumarin primarily for research and chemical synthesis purposes. The specific assay and grade are available upon request, and it is not represented as USP/BP/EP grade.
What are the safety considerations when handling 7-Fluoro-4-hydroxycoumarin?
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7-Fluoro-4-hydroxycoumarin is classified with the GHS07 symbol and a Warning signal word. It carries the hazard statement H302, indicating it is harmful if swallowed. Appropriate personal protective equipment should be used during handling.
Is 7-Fluoro-4-hydroxycoumarin available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 7-Fluoro-4-hydroxycoumarin. Please contact us for export inquiries and details.
How can I request a quote or sample for 7-Fluoro-4-hydroxycoumarin?
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To request a quote or sample for 7-Fluoro-4-hydroxycoumarin, please visit the product page on the Tech Serve Solutions website or contact our sales department directly.
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