6-(trifluoromethyl)pyridine-3-sulfonyl chloride
6-(trifluoromethyl)pyridine-3-sulfonyl chloride (CAS 959996-58-8), a chemical intermediate with the formula C6H3ClF3NO2S, has a molecular weight of 245.61. This compound is characterised by its sulfonyl chloride functional group and trifluoromethyl substituent on a pyridine ring, making it a valuable building block. It is primarily utilised in complex organic synthesis and the development of novel chemical entities within research and industrial settings.

Organic Synthesis Intermediate
Serves as a key building block in the synthesis of more complex organic molecules. Its reactive sulfonyl chloride group allows for facile derivatisation in various coupling and substitution reactions.
Pharmaceutical Research
Utilised in the exploration and development of new pharmaceutical agents. The trifluoromethylpyridine motif is found in several bioactive compounds, making this a relevant starting material for medicinal chemistry programmes.
Agrochemical Development
Can be employed in the synthesis of novel agrochemicals. Pyridine derivatives are common structural elements in pesticides and herbicides, suggesting potential applications in this field.
Materials Science
Investigated for its potential use in the development of new materials. The unique electronic properties conferred by the trifluoromethyl group and the pyridine ring may be exploited in functional material design.
| Molecular weight | 245.61 |
|---|---|
| Empirical formula | C6H3ClF3NO2S |
| Assay | 97% |
| Melting point | 40-45 °C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | >110 °C / >230 °F |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-(trifluoromethyl)pyridine-3-sulfonyl chloride primarily used for?
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6-(trifluoromethyl)pyridine-3-sulfonyl chloride is primarily used as a building block in complex organic synthesis, particularly in pharmaceutical and agrochemical research and development.
What is the CAS number and chemical formula?
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The CAS number is 959996-58-8 and the chemical formula is C6H3ClF3NO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of 97%. It is supplied as a research or technical grade chemical and is not represented as USP, BP, or EP grade.
How should 6-(trifluoromethyl)pyridine-3-sulfonyl chloride be handled safely?
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This compound is classified as a danger with hazard statement H314, indicating it causes severe skin burns and eye damage. Appropriate personal protective equipment, including gloves, eye protection, and protective clothing, must be worn. Handle in a well-ventilated area and follow all precautionary statements (P280, P305 + P351 + P338, P310).
Is this chemical shipped internationally?
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Yes, Tech Serve Solutions, as a specialist global supplier and exporter since 1998, exports chemicals worldwide, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote?
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To request a sample or a quotation for 6-(trifluoromethyl)pyridine-3-sulfonyl chloride, please contact our sales department through the website or by phone, providing your specific requirements.
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