6-O-Methylguanine
6-O-Methylguanine (CAS: 20535-83-5) is a purine derivative with the molecular formula C6H7N5O. This bioactive small molecule serves as a crucial building block in chemical synthesis and cell biology research. Its applications span the investigation of DNA repair mechanisms and as a reagent in the development of novel heterocyclic compounds. TSS provides high-quality 6-O-Methylguanine for demanding scientific and industrial applications.
- IUPAC
- 2-Amino-6-methoxypurine,6-Methoxyguanine

DNA Repair Research
6-O-Methylguanine is a key intermediate in understanding DNA alkylation and repair pathways, particularly the action of O6-alkylguanine-DNA alkyltransferase (MGMT). Researchers utilise it to study genotoxicity and mutagenicity.
Chemical Synthesis
As a heterocyclic building block, it is employed in the synthesis of complex organic molecules and potential pharmaceutical candidates. Its purine structure makes it valuable for creating modified nucleosides and related compounds.
Cell Biology Studies
This compound aids in investigations related to cellular processes influenced by DNA damage and repair, contributing to a deeper understanding of cell cycle regulation and apoptosis.
| Molecular weight | 165.15 |
|---|---|
| Empirical formula | C6H7N5O |
| Assay | 97% |
| Melting point | >300 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CDK2(1017), MGMT(4255) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-O-Methylguanine used for?
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6-O-Methylguanine is used in DNA repair research, chemical synthesis as a building block, and in cell biology studies.
What are the CAS number and formula for 6-O-Methylguanine?
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The CAS number is 20535-83-5, and the empirical formula is C6H7N5O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-O-Methylguanine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling requirements for 6-O-Methylguanine?
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Handling 6-O-Methylguanine requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It is classified under WGK Germany 3.
How is 6-O-Methylguanine packed, shipped, and exported?
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Tech Serve Solutions expertly packs, ships, and exports fine chemicals globally, adhering to all relevant regulations for safe and timely delivery.
How can I request a sample or quote for 6-O-Methylguanine?
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To request a sample or quote for 6-O-Methylguanine, please contact our sales team via the website or by phone.
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