6-Fluoro-3-pyridinylboronic acid
6-Fluoro-3-pyridinylboronic acid (CAS 351019-18-6) is a heterocyclic boronic acid derivative with the molecular formula C5H5BFNO2 and a molecular weight of 140.91. This organometallic reagent is primarily utilised in organic synthesis. It serves as a key building block in the preparation of various complex molecules, notably in the synthesis of halohydroxypyridines through hydroxydeboronation reactions, offering a versatile route for introducing fluorinated pyridine moieties into target structures.
- IUPAC
- 2-Fluoro-5-pyridylboronic acid
- Synonyms
- 2-Fluoro-5-pyridylboronic acid
Synthesis of Halohydroxypyridines
6-Fluoro-3-pyridinylboronic acid is instrumental in the synthesis of halohydroxypyridines. The compound undergoes hydroxydeboronation using basic hydrogen peroxide, providing an efficient method for preparing functionalised pyridine derivatives.
Heteroaryl Boronic Acid Intermediate
As a heteroaryl boronic acid, this compound acts as a valuable intermediate in cross-coupling reactions and other synthetic transformations. It enables the introduction of the 6-fluoro-3-pyridinyl group into diverse organic scaffolds.
Chemical Synthesis Reagent
This boronic acid derivative is employed in general chemical synthesis for the construction of novel compounds. Its reactivity profile makes it suitable for applications requiring the specific structural features of fluorinated pyridines.
| Molecular weight | 140.91 |
|---|---|
| Empirical formula | C5H5BFNO2 |
| Application | Used in a synthesis of halohydroxypyridines by hydroxydeboronation with basic hydrogen peroxide.1 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Fluoro-3-pyridinylboronic acid used for?
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6-Fluoro-3-pyridinylboronic acid is used in organic synthesis, particularly for the preparation of halohydroxypyridines via hydroxydeboronation reactions, and as a general intermediate for introducing fluorinated pyridine moieties.
What are the CAS number and molecular formula for 6-Fluoro-3-pyridinylboronic acid?
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The CAS number is 351019-18-6, and the molecular formula is C5H5BFNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and development purposes. The precise assay and grade are available upon request and are not guaranteed to meet pharmacopoeial standards (e.g., USP, EP, BP).
How should 6-Fluoro-3-pyridinylboronic acid be handled?
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Handling requires a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid breathing dust. In case of contact with eyes, rinse cautiously with water for several minutes and seek medical advice. Ensure adequate ventilation.
Is 6-Fluoro-3-pyridinylboronic acid a controlled substance?
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The provided data does not indicate that 6-Fluoro-3-pyridinylboronic acid is a controlled substance.
How is this product packaged and shipped?
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Tech Serve Solutions exports fine chemicals globally. Packaging details and shipping information are available upon inquiry.
How can I request a quote or sample?
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Please contact our sales department directly through our website or by phone to request a quote or sample of 6-Fluoro-3-pyridinylboronic acid.
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