6-Chloro-3,4-dihydro-2(1H)-naphthalenone
6-Chloro-3,4-dihydro-2(1H)-naphthalenone (CAS 17556-18-2) is a chlorinated cyclic ketone with the molecular formula C10H9ClO and a molecular weight of 180.63 g/mol. This organic building block serves as a valuable reactant in various chemical synthesis pathways. Its applications include its use in organocatalytic domino reactions and enantioselective reductions, contributing to the preparation of diverse biologically and pharmacologically significant molecules.
- IUPAC
- 6-Chloro-3,4-dihydro-1H-naphthalen-2-one,6-Chloro-3,4-dihydronaphthalen-2(1H)-one,6-Chloro-β-tetralone,6-Chloro-2-tetralone
- Synonyms
- 6-Chloro-3,4-dihydro-1H-naphthalen-2-one6-Chloro-3,4-dihydronaphthalen-2(1H)-one6-Chloro-β-tetralone6-Chloro-2-tetralone
Organocatalytic Domino Michael-Hemiacetalization
This compound functions as a key reactant in organocatalytic domino Michael-hemiacetalization reactions, enabling complex molecular transformations.
Enantioselective Reduction
It is employed as a substrate in enantioselective reduction processes, such as those mediated by the fungus Didymosphaeria igniaria, for stereospecific synthesis.
Synthesis of Bioactive Molecules
6-Chloro-3,4-dihydro-2(1H)-naphthalenone is utilised in the preparation of molecules with demonstrated biological and pharmacological activity, highlighting its importance in medicinal chemistry research.
| Molecular weight | 180.63 |
|---|---|
| Empirical formula | C10H9ClO |
| Assay | ≥94% |
| Application | Reactant for:• Organocatalytic domino Michael-hemiacetalization1• Enantioselective reduction by Didymosphaeria igniaria2• Preparation of biologically and pharmacologically active molecules3,4 |
| Melting point | 60-65 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H317May cause an allergic skin reaction
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-43 |
| Safety statements (S) | 37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What are the primary applications of 6-Chloro-3,4-dihydro-2(1H)-naphthalenone?
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It is used as a reactant in organocatalytic domino Michael-hemiacetalization, for enantioselective reduction by Didymosphaeria igniaria, and in the preparation of biologically and pharmacologically active molecules.
What is the CAS number and molecular formula for this compound?
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The CAS number is 17556-18-2 and the molecular formula is C10H9ClO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of ≥94%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 6-Chloro-3,4-dihydro-2(1H)-naphthalenone be handled safely?
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This compound is classified as harmful if swallowed and may cause an allergic skin reaction. Appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, face shields, and gloves, should be worn. Handle in a well-ventilated area.
Is 6-Chloro-3,4-dihydro-2(1H)-naphthalenone a controlled substance?
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The provided data does not indicate that 6-Chloro-3,4-dihydro-2(1H)-naphthalenone is a controlled substance.
How can I request a sample or quote for 6-Chloro-3,4-dihydro-2(1H)-naphthalenone?
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Please contact our sales team via the website or email to request a sample or a quotation for 6-Chloro-3,4-dihydro-2(1H)-naphthalenone.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and we can arrange shipment and export of 6-Chloro-3,4-dihydro-2(1H)-naphthalenone in compliance with international regulations.
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