6-Bromo-3-pyridinylboronic acid

CAS 223463-14-7Br(C5H3N)B(OH)2Chemical Synthesis

6-Bromo-3-pyridinylboronic acid (CAS: 223463-14-7) is a heteroaryl boronic acid derivative with the molecular formula Br(C5H3N)B(OH)2 and a molecular weight of 201.81 g/mol. This organometallic reagent is primarily employed as a reactant in sophisticated organic synthesis, particularly in cross-coupling reactions and the formation of complex molecular scaffolds.

IUPAC: 2-Bromopyridine-5-boronic acid
Synonyms: 2-Bromopyridine-5-boronic acid

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6-Bromo-3-pyridinylboronic acid (Br(C5H3N)B(OH)2) — chemical structure, CAS 223463-14-7; Chemistry, fine chemical supplied by Tech Serve Solutions

Boronic AcidsChemical SynthesisHeteroaryl Boronic AcidsOrganometallic Reagents

01 /Applications

Synthesis of Terpyridines

This boronic acid serves as a key reactant in iterative cross-coupling reactions, facilitating the synthesis of non-cytotoxic terpyridine structures.

Garlanding Approach

It is utilised in the Garlanding approach, a synthetic strategy for constructing phenyl-pyridyl molecular scaffolds.

Cyanation Reactions

6-Bromo-3-pyridinylboronic acid is involved in cyanation reactions for the preparation of various aromatic nitriles.

Suzuki-Miyaura Cross-Coupling

The compound participates in Suzuki-Miyaura cross-coupling reactions with dihalopyridines and dihalobipyridines, enabling the formation of carbon-carbon bonds.

Petasis Boronic Mannich Reaction

It can be employed in the Petasis boronic Mannich reaction, a multicomponent reaction for synthesizing substituted amines.

02 /Properties

Molecular weight	201.81
Linear formula	Br(C5H3N)B(OH)2
Assay	≥95%
Storage temperature	2-8°C
Application	Reactant involved in:• Iterative cross-coupling reactions for synthesis of non-cytotoxic terpyridines1• The Garlanding approach for synthesis of phenyl-pyridyl scaffolds2• Cyanation for synthesis of aromatic nitriles3• Suzuki-Miyaura cross-coupling with dihalopyridines and dihalobipyridines4• Petasis boronic Mannich reaction5
Melting point	161-166 °C

03 /Identifiers & registry

CAS number

223463-14-7

MDL number

MFCD03411558

PubChem substance

24884805

04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is 6-Bromo-3-pyridinylboronic acid used for?

6-Bromo-3-pyridinylboronic acid is used as a reactant in various organic synthesis applications, including iterative cross-coupling reactions, the Garlanding approach for phenyl-pyridyl scaffolds, cyanation for aromatic nitriles, Suzuki-Miyaura cross-coupling, and the Petasis boronic Mannich reaction.

What are the CAS number and chemical formula?

The CAS number is 223463-14-7 and the chemical formula is Br(C5H3N)B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 6-Bromo-3-pyridinylboronic acid with an assay of ≥95%. TSS does not represent this product as USP, BP, or EP grade.

What are the safety and handling considerations?

This compound is classified under WGK 3 (Germany). It is important to handle it with appropriate personal protective equipment in a well-ventilated area, following standard laboratory safety protocols for hazardous chemicals.

How is the product shipped and exported?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, equipped to handle international shipping and export requirements for compounds like 6-Bromo-3-pyridinylboronic acid.

How can I request a sample or quote?

To request a sample or a quote for 6-Bromo-3-pyridinylboronic acid, please contact our sales team through the TSS website or via the provided contact details.