6-Benzoyl-2-naphthol
6-Benzoyl-2-naphthol (CAS: 52222-87-4), with the molecular formula C6H5COC10H6OH and a molecular weight of 248.28 g/mol, is a valuable organic compound. It functions as a key intermediate in chemical synthesis. This compound is particularly noted for its use in preparing substrates for histochemical investigations, specifically for studying aryl sulfatase and acid phosphatase activity in biological tissues.
- IUPAC
- 6-Hydroxy-2-naphthyl phenyl ketone

Histochemical Substrate Synthesis
6-Benzoyl-2-naphthol is utilised in the preparation of specific substrates, such as potassium 6-benzoyl-2-naphthyl sulfate. These substrates are essential tools for the histochemical investigation of enzyme activity, notably aryl sulfatase.
Enzyme Activity Studies
The compound serves as a precursor in creating substrates employed for the histochemical demonstration of acid phosphatase activity. This application is crucial for biological research, particularly in studying enzyme distribution within organs, such as those of the albino rat.
Organic Synthesis Intermediate
As a ketone and a naphthol derivative, 6-Benzoyl-2-naphthol acts as a versatile building block in organic synthesis. Its structure allows for further chemical modifications to create more complex molecules.
| Molecular weight | 248.28 |
|---|---|
| Linear formula | C6H5COC10H6OH |
| Assay | ≥98% |
| Solubility | ethanol: soluble50 mg/mL |
| Application | 6-Benzoyl-2-naphthol was used in the synthesis of potassium 6-benzoyl-2-naphthyl sulfate, substrate for histochemical investigation of aryl sulfatase activity1. It was also used in preparation of substrate for histochemical demonstration of acid phosphatase in the organs of albino rat2. |
| Melting point | 161-162 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Benzoyl-2-naphthol used for?
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6-Benzoyl-2-naphthol is primarily used as an intermediate in chemical synthesis and for preparing substrates for histochemical studies, such as investigating aryl sulfatase and acid phosphatase activity.
What is the CAS number and molecular formula for 6-Benzoyl-2-naphthol?
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The CAS number is 52222-87-4 and the molecular formula is C6H5COC10H6OH.
What grade and purity does Tech Serve Solutions supply for 6-Benzoyl-2-naphthol?
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Tech Serve Solutions supplies 6-Benzoyl-2-naphthol with an assay of \u226598%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should 6-Benzoyl-2-naphthol be handled safely?
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According to GHS regulations, 6-Benzoyl-2-naphthol is a warning signal word chemical, classified with hazards H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be used. Handle in a well-ventilated area and avoid breathing dust.
Is 6-Benzoyl-2-naphthol exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 6-Benzoyl-2-naphthol.
How can I request a sample or quote for 6-Benzoyl-2-naphthol?
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Please contact our sales team via the website or by phone to request a sample or a quotation for 6-Benzoyl-2-naphthol. Please specify the quantity required.
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