5-Iodo-2′-deoxyuridine

CAS 54-42-2C9H11IN2O5Chemical Synthesis

5-Iodo-2′-deoxyuridine (CAS: 54-42-2, Formula: C9H11IN2O5, MW: 354.10) is a halogenated pyrimidine nucleoside analog. It serves as a valuable biochemical reagent, particularly in chemical biology and enzyme inhibition studies. This compound is also utilized in chemical synthesis and as a substrate analog in research applications, offering specific properties for biochemical investigations.

IUPAC: 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil,2′-Deoxy-5-iodouridine,5-IUdR,IDU,IdUrd,Idoxuridine
Synonyms: 2′-Deoxy-5-iodouridine5-IUdRIDUIdoxuridineIdUrd1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil

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5-Iodo-2′-deoxyuridine (C9H11IN2O5) — chemical structure, CAS 54-42-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Biochemicals and ReagentsChemical BiologyChemical SynthesisEnzyme InhibitorsEnzyme Inhibitors by TypeEnzymesInhibitorsand SubstratesNucleobaseNucleoside Chemistry

01 /Applications

Biochemical Research

5-Iodo-2′-deoxyuridine is widely employed in biochemical research as a tool for studying DNA replication and repair mechanisms. Its incorporation into DNA allows for the tracking and analysis of genetic processes.

Enzyme Inhibition Studies

As an enzyme inhibitor, this compound is used to investigate the activity of various enzymes involved in nucleic acid metabolism. It acts as a substrate analog, providing insights into enzyme kinetics and mechanisms.

Chemical Synthesis

5-Iodo-2′-deoxyuridine serves as a building block or intermediate in the synthesis of more complex nucleoside derivatives and modified nucleic acids for research purposes.

Chemical Biology

This compound is instrumental in chemical biology for developing probes and investigating cellular processes at a molecular level. Its unique structure facilitates specific interactions within biological systems.

02 /Properties

Molecular weight	354.10
Empirical formula	C9H11IN2O5
Assay	≥98.0% (NT)
Optical activity	[α]20/D +29±2°, c = 1% in 1 M NaOH
Storage temperature	2-8°C
Melting point	194 °C(lit.)

03 /Safety & handling

Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	45-46-61
Safety statements (S)	53-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

54-42-2

MDL number

MFCD00134656

Beilstein registry

30397

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 5-Iodo-2′-deoxyuridine used for?

5-Iodo-2′-deoxyuridine is used in biochemical research, chemical biology, chemical synthesis, and as an enzyme inhibitor and substrate analog.

What are the CAS number and formula for 5-Iodo-2′-deoxyuridine?

The CAS number is 54-42-2 and the empirical formula is C9H11IN2O5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 5-Iodo-2′-deoxyuridine with an assay of ≥98.0% (NT). We do not represent this product as USP, BP, EP or other pharmacopoeia grades.

How should 5-Iodo-2′-deoxyuridine be handled and stored?

5-Iodo-2′-deoxyuridine is classified as T (Toxic) with European risk statements R45 (May cause cancer), R46 (May cause heritable genetic damages), and R61 (May cause harm to the unborn child). Handle with extreme caution, observe safety statements S53 (Avoid exposure – obtain special instructions before use) and S45 (In case of accident or if you feel unwell seek medical advice immediately). Store at 2-8°C.