5-Chloro-3-pyridineboronic acid
5-Chloro-3-pyridineboronic acid (CAS: 872041-85-5; C5H5BClNO2) is a valuable organoboron compound with a molecular weight of 157.36 g/mol. This white to off-white solid functions as a key building block in organic synthesis, particularly in cross-coupling reactions. Its utility is prominent in the development of novel pharmaceuticals and advanced materials, serving as a crucial intermediate for introducing the 3-chloro-5-pyridyl moiety into complex molecular architectures.
- IUPAC
- (3-Chloro-5-pyridyl)boronic acid,(3-Chloropyridin-5-yl)boronic acid,(5-Chloropyridin-3-yl)boronic acid,3-Chloropyridine-5-boronic acid,5-Chloropyridine-3-boronic acid
- Synonyms
- (3-Chloro-5-pyridyl)boronic acid(3-Chloropyridin-5-yl)boronic acid(5-Chloropyridin-3-yl)boronic acid3-Chloropyridine-5-boronic acid5-Chloropyridine-3-boronic acid
Suzuki-Miyaura Coupling Reagent
5-Chloro-3-pyridineboronic acid is frequently employed as a coupling partner in Suzuki-Miyaura reactions. This facilitates the formation of carbon-carbon bonds, enabling the synthesis of biaryl compounds and complex heteroaromatic systems.
Pharmaceutical Intermediate
This boronic acid derivative is utilised in the synthesis of active pharmaceutical ingredients (APIs). Its pyridine core and chloro-substituent make it a versatile precursor for drug discovery programmes targeting various therapeutic areas.
Materials Science
The compound can be incorporated into the design of novel organic materials, such as those for organic light-emitting diodes (OLEDs) or other electronic applications, where specific electronic and structural properties are desired.
Agrochemical Development
It serves as an intermediate in the research and development of new agrochemicals, contributing to the creation of molecules with potential pesticidal or herbicidal activity.
| Molecular weight | 157.36 |
|---|---|
| Empirical formula | C5H5BClNO2 |
| Assay | ≥95% |
| Storage temperature | 2-8°C |
| Melting point | 255-260 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-3-pyridineboronic acid used for?
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5-Chloro-3-pyridineboronic acid is primarily used as a building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions for the development of pharmaceuticals, agrochemicals, and advanced materials.
What are the CAS number and molecular formula for 5-Chloro-3-pyridineboronic acid?
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The CAS number for 5-Chloro-3-pyridineboronic acid is 872041-85-5, and its molecular formula is C5H5BClNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Chloro-3-pyridineboronic acid with an assay of ≥95%. We do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.
What are the safety and handling precautions for 5-Chloro-3-pyridineboronic acid?
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5-Chloro-3-pyridineboronic acid is classified as a Warning. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment (gloves, eye protection, respiratory protection) in a well-ventilated area. Avoid inhalation and contact with skin and eyes. Refer to the Safety Data Sheet for detailed information.
How is 5-Chloro-3-pyridineboronic acid packaged and shipped?
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5-Chloro-3-pyridineboronic acid is typically packaged in quantities suitable for laboratory and industrial use and is exported globally by Tech Serve Solutions, adhering to all relevant shipping regulations.
How can I request a sample or quote for 5-Chloro-3-pyridineboronic acid?
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To request a sample or a quotation for 5-Chloro-3-pyridineboronic acid, please contact our sales team through the website or by phone, providing your specific requirements.
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