5-Bromo-1-pentene
5-Bromo-1-pentene (CAS: 1119-51-3), with the linear formula Br(CH2)3CH=CH2 and a molecular weight of 149.03 g/mol, is a halogenated hydrocarbon and organic building block. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of complex molecules. Its reactivity stems from the presence of both an alkene and an alkyl bromide functional group, enabling diverse chemical transformations.
Synthesis of Steroid Derivatives
5-Bromo-1-pentene has been employed in the stereoselective synthesis of biologically significant steroid derivatives, such as 7α-(3-carboxypropyl) estradiol. This application highlights its utility in constructing complex polycyclic structures.
Preparation of Glycosidic Linkages
This compound was utilized in the preparation of sialic acid derivatives, specifically forming thioacetate 11. This demonstrates its role in the synthesis of molecules featuring thioglycosidic linkages.
Natural Product Synthesis
5-Bromo-1-pentene has served as a starting material in the total synthesis of complex natural products. Notable examples include its use in recent syntheses of DL-histrionicotoxin and benzophenone-containing fatty acids.
| Molecular weight | 149.03 |
|---|---|
| Linear formula | Br(CH2)3CH=CH2 |
| Assay | 95% |
| Boiling point | 126-127 °C/765 mmHg(lit.) |
| Density | 1.258 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.463(lit.) |
| Storage temperature | 2-8°C |
| Application | 5-Bromo-1-pentene was used in stereoselective synthesis of 7α-(3-carboxypropyl) estradiol1. It was used in preparation of thioacetate 11 of sialic acid having thioglycosidic linkage2. It was also used as staring material in recent syntheses of DL-histrionicotoxin3 and benzophenone-containing fatty acids4. |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 31 °C / 87.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Bromo-1-pentene used for?
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5-Bromo-1-pentene is primarily used as a versatile intermediate and building block in organic synthesis. It has been applied in the preparation of steroid derivatives, sialic acid compounds with thioglycosidic linkages, DL-histrionicotoxin, and benzophenone-containing fatty acids.
What is the CAS number and formula for 5-Bromo-1-pentene?
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The CAS number for 5-Bromo-1-pentene is 1119-51-3, and its linear formula is Br(CH2)3CH=CH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Bromo-1-pentene with an assay of 95%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should 5-Bromo-1-pentene be handled safely?
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5-Bromo-1-pentene is a flammable liquid and vapour (H226) and causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle in a well-ventilated area, away from ignition sources, and wear appropriate personal protective equipment including eyeshields, gloves, and respiratory protection.
How is 5-Bromo-1-pentene packed and shipped?
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5-Bromo-1-pentene is typically packed and shipped according to its UN classification (UN 1993, Class 3, PGIII) and relevant transport regulations for flammable liquids.
How can I request a quote or sample for 5-Bromo-1-pentene?
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To request a quote or sample for 5-Bromo-1-pentene, please contact the Tech Serve Solutions sales team through our website or by phone, providing your specific requirements.
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