5-Amino-4,6-dichloropyrimidine
5-Amino-4,6-dichloropyrimidine (CAS: 5413-85-4) is a halogenated heterocyclic compound with the molecular formula C4H3Cl2N3 and a molecular weight of 163.99 g/mol. Utilised as a key building block in chemical synthesis, it is particularly valuable in the creation of complex organic molecules. This compound is supplied by Tech Serve Solutions with an assay of 97% and is recommended for storage at 2-8°C.
- Synonyms
- 5-Amino-4,6-dichloropyrimidineC4H3Cl2N3
Synthesis of Nucleoside Analogues
5-Amino-4,6-dichloropyrimidine serves as a precursor in the synthesis of various nucleoside analogues, including those with oxepane rings and conformationally locked bicyclo[2.2.1]heptane/oxa-bicyclo[3.2.1]octane structures.
Preparation of Substituted Purines
This compound is employed in the preparation of N(7)-substituted purines and 9-alkyl-6-substituted-purine analogues, some of which have demonstrated potent anticonvulsant properties.
Development of Pyrimido-Oxazepines
It is used in a three-step process, often utilising microwave heating, for the synthesis of pyrimido-oxazepines.
| Molecular weight | 163.99 |
|---|---|
| Empirical formula | C4H3Cl2N3 |
| Assay | 97% |
| Solubility | 95% ethanol: soluble50 mg/mL, clear to slightly hazy, colorless to faintly yellow |
| Storage temperature | 2-8°C |
| Application | 5-Amino-4,6-dichloropyrimidine was used in the synthesis of:• oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides1• conformationally locked bicyclo[2.2.1]heptane/oxa-bicyclo[3.2.1]octane nucleosides2• N(7)-substituted purines3• chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine4• 9-alkyl-6-substituted-purine analogs, potent anticonvulsant agents5• pyrimido-oxazepines in a three-step process with microwave heating at 150°C6 |
| Melting point | 145-148 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Amino-4,6-dichloropyrimidine used for?
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5-Amino-4,6-dichloropyrimidine is primarily used as a building block in chemical synthesis, particularly for creating nucleoside analogues, substituted purines, and pyrimido-oxazepines.
What are the CAS number and formula for 5-Amino-4,6-dichloropyrimidine?
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The CAS number is 5413-85-4 and the empirical formula (Hill notation) is C4H3Cl2N3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Amino-4,6-dichloropyrimidine with an assay of 97%. This product is not intended for pharmaceutical, food, or any regulated use unless otherwise specified, and we do not represent it as USP, BP, or EP grade.
What are the safety and handling requirements for 5-Amino-4,6-dichloropyrimidine?
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This compound is classified with a Warning signal word and carries hazard statements H315, H319, and H335, indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Recommended personal protective equipment includes a dust mask (type N95), eyeshields, and gloves. Handle in a well-ventilated area and avoid dust formation.
How is 5-Amino-4,6-dichloropyrimidine shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Detailed shipping and export information can be provided upon request.
How can I request a sample or quote for 5-Amino-4,6-dichloropyrimidine?
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To request a sample or a quote for 5-Amino-4,6-dichloropyrimidine, please contact our sales team through the website or by phone.
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