5-(4-Hydroxyphenyl)-5-phenylhydantoin
5-(4-Hydroxyphenyl)-5-phenylhydantoin (CAS: 2784-27-2; Formula: C15H12N2O3; MW: 268.27) is a white to off-white solid, primarily utilised as a key building block in chemical synthesis and heterocyclic chemistry. It serves as a valuable reagent in analytical chemistry, for example, as an internal standard in the determination of certain pharmaceutical compounds. Its unique structure lends itself to applications in advanced organic synthesis and materials science.
- IUPAC
- 4-Hydroxydiphenylhydantoin,p-Hydroxyphenytoin,NSC 156081
- Synonyms
- 4-Hydroxydiphenylhydantoinp-HydroxyphenytoinNSC 156081
Chiral Separations
This compound has been employed in enantiomeric separation techniques for chiral pharmaceuticals, specifically utilising a teicoplanin chiral stationary phase in packed capillary electrochromatography.
Analytical Standard
It has served as an internal standard in gas-liquid chromatography (GLC) for the precise determination of phenylbutazone and its metabolite, oxyphenbutazone, in human plasma samples.
Organic Synthesis Intermediate
As a hydantoin derivative, it functions as a versatile building block for the synthesis of more complex organic molecules and heterocyclic compounds.
| Molecular weight | 268.27 |
|---|---|
| Empirical formula | C15H12N2O3 |
| Assay | 98% |
| Solubility | : soluble50 mg/mL, clear, colorless to faintly yellow (DMF:MeOH(2:1)) |
| Application | 5-(4-Hydroxyphenyl)-5-phenylhydantoin was used in enantiomeric separation of chiral pharmaceuticals using a teicoplanin chiral stationary phase by aqueous and non-aqueous packed capillary electrochromatography1. It was used as internal standard in determination of phenylbutazone and its metabolite oxyphenbutazone in human plasma by GLC2. |
| Melting point | >300 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-(4-Hydroxyphenyl)-5-phenylhydantoin used for?
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5-(4-Hydroxyphenyl)-5-phenylhydantoin is used as a building block in chemical synthesis, for enantiomeric separation of chiral pharmaceuticals, and as an internal standard in analytical chemistry for determining specific drug compounds.
What is the CAS number and molecular formula?
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The CAS number for 5-(4-Hydroxyphenyl)-5-phenylhydantoin is 2784-27-2, and its molecular formula is C15H12N2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-(4-Hydroxyphenyl)-5-phenylhydantoin with a minimum assay of 98%. This product is supplied for research and development purposes and is not represented as USP, EP, BP, or any other pharmacopoeia grade.
How should 5-(4-Hydroxyphenyl)-5-phenylhydantoin be handled?
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5-(4-Hydroxyphenyl)-5-phenylhydantoin is a Warning substance that can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). When handling, use a dust mask type N95 (US), wear eyeshields and gloves. Ensure adequate ventilation. Avoid breathing dust.
Is this chemical exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 5-(4-Hydroxyphenyl)-5-phenylhydantoin.
How can I request a sample or quote?
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To request a sample or a quotation for 5-(4-Hydroxyphenyl)-5-phenylhydantoin, please contact our sales department through the website or by calling us directly.
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