4-(Trimethylsilyl)morpholine
4-(Trimethylsilyl)morpholine (CAS: 13368-42-8) is a versatile organosilicon compound with the molecular formula C7H17NOSi and a molecular weight of 159.30 g/mol. This heterocyclic building block serves as a valuable reagent in chemical synthesis, particularly noted for its application in the deoxynucleoside synthesis. Its unique structure makes it a useful intermediate for creating more complex molecules in research and development settings.

Deoxynucleoside Synthesis
4-(Trimethylsilyl)morpholine acts as a key reagent in the synthesis of deoxynucleosides. This application is crucial for the development of nucleoside analogues used in various biochemical and pharmaceutical research areas.
Chemical Synthesis Intermediate
As a heterocyclic building block, it is employed in organic synthesis to introduce specific structural motifs. Its reactivity profile allows for its use in constructing complex molecular architectures.
Research and Development
This compound is valuable for laboratory research and development purposes, enabling chemists to explore novel synthetic pathways and create new chemical entities.
| Molecular weight | 159.30 |
|---|---|
| Empirical formula | C7H17NOSi |
| Assay | 97% |
| Boiling point | 160 °C(lit.) |
| Density | 0.897 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.441(lit.) |
| Application | Reagent for deoxynucleoside synthesis. |


Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 29 °C / 84.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trimethylsilyl)morpholine used for?
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4-(Trimethylsilyl)morpholine (CAS: 13368-42-8) is primarily used as a reagent in the synthesis of deoxynucleosides and as a general intermediate in chemical synthesis.
What is the CAS number and chemical formula for 4-(Trimethylsilyl)morpholine?
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The CAS number for 4-(Trimethylsilyl)morpholine is 13368-42-8, and its empirical formula is C7H17NOSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trimethylsilyl)morpholine with an assay of 97%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
How should 4-(Trimethylsilyl)morpholine be handled safely?
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4-(Trimethylsilyl)morpholine is a flammable liquid and causes severe skin burns and eye damage (H226-H314). Handle with extreme care using appropriate personal protective equipment, including face shields, gloves, and suitable respiratory protection. Ensure good ventilation and avoid sources of ignition.
Is 4-(Trimethylsilyl)morpholine available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 4-(Trimethylsilyl)morpholine, and can arrange for international shipment.
How can I request a sample or quote for 4-(Trimethylsilyl)morpholine?
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To request a sample or a quote for 4-(Trimethylsilyl)morpholine, please contact our sales team through the website or by phone, providing your specific requirements.
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