4-Methyl-3-nitrophenylboronic acid
4-Methyl-3-nitrophenylboronic acid (CAS: 80500-27-2), with the molecular formula C7H8BNO4 and a molecular weight of 180.95 g/mol, is a disubstituted aryl boronic acid. It serves as a key reactant in sophisticated organic synthesis, notably in Suzuki-Miyaura coupling reactions. Its applications extend to the preparation of novel chemical entities with potential therapeutic applications, including inhibitors of lactate dehydrogenase and iodide efflux inhibitors.
- IUPAC
- 3-Nitro-4-methylbenzeneboronic acid,3-Nitro-4-methylphenylboronic acid
Suzuki-Miyaura Coupling Reactions
4-Methyl-3-nitrophenylboronic acid is a valuable building block in Suzuki-Miyaura coupling reactions, enabling the formation of carbon-carbon bonds with aryl or vinyl halides. This widely used cross-coupling methodology is fundamental in constructing complex organic molecules for pharmaceutical and materials science research.
Preparation of Cancer Cell Proliferation Inhibitors
This compound has been employed as a reactant in the synthesis of inhibitors targeting lactate dehydrogenase. Such inhibitors are investigated for their potential in modulating cancer cell proliferation, highlighting its role in medicinal chemistry research.
Synthesis of Imidazothiazoles
It is utilised in the preparation of imidazothiazoles, which have been studied for their activity as iodide efflux inhibitors in thyrocytes. This application underscores its utility in developing agents for research into thyroid function.
| Molecular weight | 180.95 |
|---|---|
| Linear formula | CH3C6H3(NO2)B(OH)2 |
| Application | Reactant for:• Preparation of inhibitors of lactate dehydrogenase against cancer cell proliferation1• Suzuki-Miyaura coupling reactions2,3• Preparation of imidazothiazoles as iodide efflux inhibitors in thyrocytes4 |
| Melting point | 265-270 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methyl-3-nitrophenylboronic acid used for?
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4-Methyl-3-nitrophenylboronic acid is used as a reactant in organic synthesis, particularly for Suzuki-Miyaura coupling reactions. It is also employed in the preparation of inhibitors of lactate dehydrogenase against cancer cell proliferation and in the synthesis of imidazothiazoles as iodide efflux inhibitors.
What are the CAS number and molecular formula for 4-Methyl-3-nitrophenylboronic acid?
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The CAS number for 4-Methyl-3-nitrophenylboronic acid is 80500-27-2, and its molecular formula is C7H8BNO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and development purposes. The specific assay and grade will be detailed on the Certificate of Analysis provided with the product. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling 4-Methyl-3-nitrophenylboronic acid?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified under WGK Germany 3.
How is 4-Methyl-3-nitrophenylboronic acid exported and shipped?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. We ensure compliant packaging and shipping procedures for international export, adhering to all relevant regulations for hazardous materials.
How can I request a sample or quote for 4-Methyl-3-nitrophenylboronic acid?
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To request a sample or a quotation, please contact our sales team through the website or by phone. Provide the product name and CAS number (80500-27-2) for efficient processing.
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